U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ribB 3,4-dihydroxy-2-butanone-4-phosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947526, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ribB
    Official Full Name
    3,4-dihydroxy-2-butanone-4-phosphate synthase
    Primary source
    ECOCYC:EG10465
    Locus tag
    b3041
    See related
    ASAP:ABE-0009980
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3032; htrP; luxH; luxH-l
    Summary
    RibB catalyzes the synthesis of the 4-carbon compound 3,4-dihydroxy-2-butanone-4-phosphate, a precursor of the terminal intermediate, 6,7-dimethyl-8-ribityllumazine, in the biosynthesis of riboflavin . [More information is available at EcoCyc: EG10465].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (3183813..3184466, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene divalent metal ion transporter ZupT Neighboring gene protein YqiD Neighboring gene ubiquinone biosynthesis accessory factor UbiK Neighboring gene putative fimbrial protein YgiL

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NMR studies on the 46-kDa dimeric protein, 3,4-dihydroxy-2-butanone 4-phosphate synthase, using 2H, 13C, and 15N-labelling. Richter G, et al. Eur J Biochem, 1999 Apr. PMID 10103033
    2. The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site. Kelly MJ, et al. Proc Natl Acad Sci U S A, 2001 Nov 6. PMID 11687623, Free PMC Article
    3. The Escherichia coli htrP gene product is essential for bacterial growth at high temperatures: mapping, cloning, sequencing, and transcriptional regulation of htrP. Raina S, et al. J Bacteriol, 1991 Oct. PMID 1917833, Free PMC Article
    4. [3 linkage groups of the genes of riboflavin biosynthesis in Escherichia coli]. Bandrin SV, et al. Genetika, 1983 Sep. PMID 6315532
    5. Selective small-molecule inhibition of an RNA structural element. Howe JA, et al. Nature, 2015 Oct 29. PMID 26416753

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate synthase of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within riboflavin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    3,4-dihydroxy-2-butanone-4-phosphate synthase
    NP_417513.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3183813..3184466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417513.1 3,4-dihydroxy-2-butanone-4-phosphate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417513.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FKK2
      Conserved Domains (1) summary
      PRK03353
      Location:1 → 217
      ribB; 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.