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    tdcB catabolic threonine dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947633, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tdcB
    Official Full Name
    catabolic threonine dehydratase
    Primary source
    ECOCYC:EG10990
    Locus tag
    b3117
    See related
    ASAP:ABE-0010249
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3106; tdc
    Summary
    The structure of Salmonella typhimurium TcdB has been determined (Simanshu, 2006). otherPDB: [More information is available at EcoGene: EG10990]. Catabolic threonine dehydratase (TdcB) carries out the first step in threonine degradation and is one of several enzymes carrying out the first step in serine degradation. [More information is available at EcoCyc: EG10990].
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    Genomic context

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    Sequence:
    NC_000913.3 (3265039..3266028, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene propionate kinase Neighboring gene threonine/serine:H(+) symporter Neighboring gene DNA-binding transcriptional activator TdcA Neighboring gene DNA-binding transcriptional activator TdcR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid sequence of the regulatory-site glyoxylate peptide of biodegradative threonine dehydratase of Escherichia coli. Patil RV, et al. J Bacteriol, 1989 Jun. PMID 2656654, Free PMC Article
    2. Studies on the interaction between regulatory enzymes and effectors. 3. Crystallization and characterization of adenosine 5'-monophosphate-dependent threonine deaminase from Escherichia coli. Shizuta Y, et al. J Biol Chem, 1969 Apr 10. PMID 4889010
    3. The mechanism of action of 5'-adenylic acid-activated threonine dehydrase. II. Protomer-oligomer interconversions and related properties. Whanger PD, et al. J Biol Chem, 1968 Jan 10. PMID 4865701
    4. Regulation of biodegradative threonine deaminase. 3. Effects of beta substituents of substrate on absorption spectrum and circular dichroism of the enzyme-bound pyridoxal phosphate. Tanabe T, et al. J Biol Chem, 1974 Feb 10. PMID 4590691
    5. Regulation of biodegradative threonine deaminase. I. Allosteric inhibition of the enzyme by a reaction product and its reversal by adenosin 5'-monophosphate. Shizuta Y, et al. J Biol Chem, 1973 Jan 25. PMID 4346334

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Chemical characterization of biodegradative threonine dehydratases from two enteric bacteria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amino acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-serine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-threonine catabolic process to propionate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within threonine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in threonine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catabolic threonine dehydratase
    NP_417587.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3265039..3266028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417587.1 catabolic threonine dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417587.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A765X568
      Conserved Domains (1) summary
      PRK08638
      Location:1 → 327
      PRK08638; bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB
    Nucleotide Protein
    Heading Accession and Version

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