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    degQ periplasmic serine endoprotease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947812, updated on 3-Dec-2024

    Summary

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    Official Symbol
    degQ
    Official Full Name
    periplasmic serine endoprotease
    Primary source
    ECOCYC:G7682
    Locus tag
    b3234
    See related
    ASAP:ABE-0010609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3223; hhoA
    Summary
    DegQ is a serine endoprotease that may be involved in degrading transiently denatured proteins . [More information is available at EcoCyc: G7682].
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    Genomic context

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    Sequence:
    NC_000913.3 (3380743..3382110)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division protein ZapE Neighboring gene Z-ring associated protein G Neighboring gene serine endoprotease Neighboring gene malate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Malet H, et al. Nat Struct Mol Biol, 2012 Jan 15. PMID 22245966, Free PMC Article
    2. Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. Sawa J, et al. J Biol Chem, 2011 Sep 2. PMID 21685389, Free PMC Article
    3. pH-dependent catabolic protein expression during anaerobic growth of Escherichia coli K-12. Yohannes E, et al. J Bacteriol, 2004 Jan. PMID 14679238, Free PMC Article
    4. Roles of DegP in prevention of protein misfolding in the periplasm upon overexpression of penicillin acylase in Escherichia coli. Pan KL, et al. J Bacteriol, 2003 May. PMID 12730160, Free PMC Article
    5. The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation. Kolmar H, et al. J Bacteriol, 1996 Oct. PMID 8830688, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Up to six lysozyme substrates bind inside the DegQ 12-mer cage and are visualized in a close-to-native state.
      Title: Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ.
    2. analysis of how the the DegQ protease exerts protein quality control in the bacterial cell envelope
      Title: Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    periplasmic serine endoprotease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3380743..3382110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417701.1 periplasmic serine endoprotease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417701.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QZL7
      Conserved Domains (1) summary
      PRK10139
      Location:1 → 455
      PRK10139; serine endoprotease DegQ
    Nucleotide Protein
    Heading Accession and Version

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