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    gor glutathione reductase (NADPH) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948014, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gor
    Official Full Name
    glutathione reductase (NADPH)
    Primary source
    ECOCYC:EG10412
    Locus tag
    b3500
    See related
    ASAP:ABE-0011432
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3485; gorA
    Summary
    Glutathione reductase is a member of the flavin-containing NADPH:disulfide oxidoreductases (DSOR) family. [More information is available at EcoCyc: EG10412].
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    Genomic context

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    Sequence:
    NC_000913.3 (3646299..3647651)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene oligopeptidase A Neighboring gene 23S rRNA m(6)A2030 methyltransferase Neighboring gene membrane toxin DinQ Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione. Holmgren A. Proc Natl Acad Sci U S A, 1976 Jul. PMID 7783, Free PMC Article
    2. Directed mutagenesis of the redox-active disulphide bridge in glutathione reductase from Escherichia coli. Deonarain MP, et al. Proc Biol Sci, 1990 Sep 22. PMID 1979442
    3. The three-dimensional structure of glutathione reductase from Escherichia coli at 3.0 A resolution. Ermler U, et al. Proteins, 1991. PMID 2006135
    4. Variations in the activity of glutathione reductase and the cellular glutathione content in relation to sensitivity to methylviologen in Escherichia coli. Kunert KJ, et al. Arch Biochem Biophys, 1990 Nov 1. PMID 2241146
    5. Isolation and mapping of glutathione reductase-negative mutants of Escherichia coli K12. Davis NK, et al. J Gen Microbiol, 1982 Jul. PMID 6214613

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    glutathione reductase (NADPH)
    NP_417957.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3646299..3647651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417957.1 glutathione reductase (NADPH) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417957.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0IIW4
      Conserved Domains (1) summary
      PRK06116
      Location:1 → 450
      PRK06116; glutathione reductase; Validated
    Nucleotide Protein
    Heading Accession and Version

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