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    zraR DNA-binding transcriptional activator ZraR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948505, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zraR
    Official Full Name
    DNA-binding transcriptional activator ZraR
    Primary source
    ECOCYC:EG10482
    Locus tag
    b4004
    See related
    ASAP:ABE-0013093
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3996; hydG
    Summary
    The N-terminal sequencing of overexpressed protein showed that the fMet is not clipped (Leonhartsberger et al. [More information is available at EcoGene: EG10482]. ZraR, "zinc resistance-associated regulator," controls the expression of genes involved in tolerance to high zinc concentrations. [More information is available at EcoCyc: EG10482].
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    Genomic context

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    Sequence:
    NC_000913.3 (4203320..4204645)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1481 domain-containing protein YjaH Neighboring gene signaling pathway modulator ZraP Neighboring gene sensor histidine kinase ZraS Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene bifunctional AICAR transformylase/IMP cyclohydrolase Neighboring gene 16S ribosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12. Stoker K, et al. J Bacteriol, 1989 Aug. PMID 2666400, Free PMC Article
    2. New insights into [FeFe] hydrogenase activation and maturase function. Kuchenreuther JM, et al. PLoS One, 2012. PMID 23049878, Free PMC Article
    3. The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli. Rome K, et al. J Mol Biol, 2018 Dec 7. PMID 30389436
    4. Structures and organisation of AAA+ enhancer binding proteins in transcriptional activation. Schumacher J, et al. J Struct Biol, 2006 Oct. PMID 16531068
    5. In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation. McGlynn SE, et al. J Biol Inorg Chem, 2007 May. PMID 17372774

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay response regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator ZraR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4203320..4204645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418432.1 DNA-binding transcriptional activator ZraR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418432.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FSU1
      Conserved Domains (1) summary
      PRK10365
      Location:1 → 441
      PRK10365; sigma-54-dependent response regulator transcription factor ZraR
    Nucleotide Protein
    Heading Accession and Version

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