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    phnN ribose 1,5-bisphosphate phosphokinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948608, updated on 17-Dec-2024

    Summary

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    Official Symbol
    phnN
    Official Full Name
    ribose 1,5-bisphosphate phosphokinase
    Primary source
    ECOCYC:EG10723
    Locus tag
    b4094
    See related
    ASAP:ABE-0013417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4087
    Summary
    Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10723]. The phnN gene encodes ribose 1,5-bisphosphokinase, which catalyzes the final step in a pathway of 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) biosynthesis . [More information is available at EcoCyc: EG10723].
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    Genomic context

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    Sequence:
    NC_000913.3 (4315525..4316082, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YjdP Neighboring gene 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase Neighboring gene aminoalkylphosphonate N-acetyltransferase Neighboring gene RPnTP hydrolase Neighboring gene methylphosphonate degradation complex subunit PhnL Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A fluorescent substrate for carbon-phosphorus lyase: towards the pathway for organophosphonate metabolism in bacteria. He SM, et al. Bioorg Med Chem Lett, 2009 Oct 15. PMID 19733071
    2. Accumulation of intermediates of the carbon-phosphorus lyase pathway for phosphonate degradation in phn mutants of Escherichia coli. Hove-Jensen B, et al. J Bacteriol, 2010 Jan. PMID 19854894, Free PMC Article
    3. Genes for phosphonate biodegradation in Escherichia coli. Wanner BL. SAAS Bull Biochem Biotechnol, 1992 Jan. PMID 1368181
    4. Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. Metcalf WW, et al. J Bacteriol, 1991 Jan. PMID 1846145, Free PMC Article
    5. Molecular genetic studies of a 10.9-kb operon in Escherichia coli for phosphonate uptake and biodegradation. Wanner BL, et al. FEMS Microbiol Lett, 1992 Dec 15. PMID 1335942

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose 1,5-bisphosphate phosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose 1,5-bisphosphate phosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose 1,5-bisphosphate phosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic phosphonate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic phosphonate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribose 1,5-bisphosphate phosphokinase
    NP_418518.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4315525..4316082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418518.1 ribose 1,5-bisphosphate phosphokinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418518.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QE76
      Conserved Domains (1) summary
      PRK10078
      Location:2 → 185
      PRK10078; ribose 1,5-bisphosphokinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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