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    yjjX inosine/xanthosine triphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948919, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yjjX
    Official Full Name
    inosine/xanthosine triphosphatase
    Primary source
    ECOCYC:EG12600
    Locus tag
    b4394
    See related
    ASAP:ABE-0014411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4386
    Summary
    ITP and XTP are products of oxidative damage and inhibitors of transcription, but the physiological significance and in vivo substrates for the in vitro triphosphatase activity is uncertain. [More information is available at EcoGene: EG12600]. YjjX is a phosphatase that preferentially hydrolyzes inosine triphosphate (ITP) and xanthosine triphosphate (XTP). [More information is available at EcoCyc: EG12600].
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    Genomic context

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    Sequence:
    NC_000913.3 (4633233..4633745, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene soluble lytic murein transglycosylase Neighboring gene DNA-binding transcriptional repressor TrpR Neighboring gene putative phosphatase Neighboring gene DNA-binding transcriptional dual regulator Rob Neighboring gene PF05981 family protein CreA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YjjX: from structure "Tu" function. Rao Z. Structure, 2005 Oct. PMID 16216571
    2. Nucleotide sequence of the Salmonella typhimurium trpR gene. Skrypka I, et al. DNA Seq, 1994. PMID 7841459
    3. Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli. Budke B, et al. Mol Microbiol, 2010 Jan. PMID 19943897, Free PMC Article
    4. DNA sequence of the E. coli trpR gene and prediction of the amino acid sequence of Trp repressor. Singleton CK, et al. Nucleic Acids Res, 1980 Apr 11. PMID 7001368, Free PMC Article
    5. Piecing together the structure-function puzzle: experiences in structure-based functional annotation of hypothetical proteins. Adams MA, et al. Proteomics, 2007 Aug. PMID 17639604

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ITPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoside triphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thiamine metabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in thiamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inosine/xanthosine triphosphatase
    NP_418811.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4633233..4633745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418811.2 inosine/xanthosine triphosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418811.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EI30
      Conserved Domains (1) summary
      PRK05074
      Location:1 → 170
      PRK05074; non-canonical purine NTP phosphatase
    Nucleotide Protein
    Heading Accession and Version

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