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    creC sensory histidine kinase CreC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948609, updated on 3-Dec-2024

    Summary

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    Official Symbol
    creC
    Official Full Name
    sensory histidine kinase CreC
    Primary source
    ECOCYC:EG10730
    Locus tag
    b4399
    See related
    ASAP:ABE-0014430
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4391; phoM
    Summary
    CreC belongs to the two component system CreC/CreB , and is involved in phosphate limitation . [More information is available at EcoCyc: EG10730].
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    Genomic context

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    Sequence:
    NC_000913.3 (4636696..4638120)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphatase Neighboring gene DNA-binding transcriptional dual regulator Rob Neighboring gene PF05981 family protein CreA Neighboring gene DNA-binding transcriptional regulator CreB Neighboring gene putative inner membrane protein CreD Neighboring gene DNA-binding transcriptional dual regulator ArcA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the alkaline phosphatase positive regulatory gene (phoM) of Escherichia coli. Makino K, et al. Mol Gen Genet, 1984. PMID 6381964
    2. The CreC Regulator of Escherichia coli, a New Target for Metabolic Manipulations. Godoy MS, et al. Appl Environ Microbiol, 2016 Jan 1. PMID 26497466, Free PMC Article
    3. Molecular cloning of the wild-type phoM operon in Escherichia coli K-12. Wanner BL, et al. J Bacteriol, 1988 Jan. PMID 3275616, Free PMC Article
    4. Identification of the phoM gene product and its regulation in Escherichia coli K-12. Ludtke D, et al. J Bacteriol, 1984 Jul. PMID 6330029, Free PMC Article
    5. Control of phoR-dependent bacterial alkaline phosphatase clonal variation by the phoM region. Wanner BL. J Bacteriol, 1987 Feb. PMID 3542979, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. work shows that CreC affects both carbon catabolism and the intracellular redox state and influences many different aspects of bacterial physiology
      Title: The CreC Regulator of Escherichia coli, a New Target for Metabolic Manipulations.
    2. CreC showed an interaction with PhoB, before an interaction between PhoB and PhoR, suggesting that this acts as a constant sensor for the early response to phosphate starvation.
      Title: Transcript and protein level analyses of the interactions among PhoB, PhoR, PhoU and CreC in response to phosphate starvation in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycolytic fermentation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sensory histidine kinase CreC
    NP_418816.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4636696..4638120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418816.1 sensory histidine kinase CreC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418816.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L5H0D1
      Conserved Domains (1) summary
      PRK11100
      Location:1 → 473
      PRK11100; sensory histidine kinase CreC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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