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    ARHGEF10 Rho guanine nucleotide exchange factor 10 [ Homo sapiens (human) ]

    Gene ID: 9639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARHGEF10provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 10provided by HGNC
    Primary source
    HGNC:HGNC:14103
    See related
    Ensembl:ENSG00000104728 MIM:608136; AllianceGenome:HGNC:14103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNCV; GEF10
    Summary
    This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Broad expression in testis (RPKM 15.4), lung (RPKM 12.1) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGEF10 in Genome Data Viewer
    Location:
    8p23.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (1823300..1958641)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (1601800..1736745)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (1772092..1906807)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1762347-1762848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1762849-1763348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1764028-1764696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1764697-1765364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1776960-1777876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1777877-1778792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1781498-1781998 Neighboring gene microRNA 596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1783384-1783975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1788613-1789492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1789493-1790372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1790373-1791250 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1791725-1792924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1813026-1813858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1821545-1822256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1829183-1829682 Neighboring gene Sharpr-MPRA regulatory region 1960 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:1854442-1855641 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1856650-1856751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1859957-1860559 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:1864189-1864688 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1870370-1871569 Neighboring gene uncharacterized LOC100131395 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1894594-1894745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1897836-1898336 Neighboring gene KBTBD11 antisense RNA 1 Neighboring gene KBTBD11 overlapping transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1926153-1926712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1926713-1927271 Neighboring gene kelch repeat and BTB domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10). Chaya T, et al. J Biol Chem, 2011 Aug 26. PMID 21719701, Free PMC Article
    2. The functional SNP rs4376531 in the ARHGEF gene is a risk factor for the atherothrombotic stroke in Han Chinese. Yin YY, et al. Neurol India, 2011 May-Jun. PMID 21743172
    3. ARHGEF10 gene polymorphism is closely associated with the risk of ischemic stroke in Northern Han Chinese population. Li H, et al. Neurol Res, 2017 Feb. PMID 27934548
    4. Association of the Charcot-Marie-Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance). Boora GK, et al. J Neurol Sci, 2015 Oct 15. PMID 26143528, Free PMC Article
    5. Rho guanine nucleotide exchange factor ARHGEF10 is a putative tumor suppressor in pancreatic ductal adenocarcinoma. Joseph J, et al. Oncogene, 2020 Jan. PMID 31477830

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption
      Title: A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption.
    2. Treatment of ARHGEF10-depleted cells with the inhibitor dasatinib reduced levels of phospho Src kinase and attenuated motility and invasion in vitro. Together, our data indicate that ARHGEF10 may function as a tumor suppressor in Pancreatic ductal adenocarcinoma (PDAC).
      Title: Rho guanine nucleotide exchange factor ARHGEF10 is a putative tumor suppressor in pancreatic ductal adenocarcinoma.
    3. it was suggested that ARHGEF10 is involved in the regulation of Rab6A and Rab8A localization and invasion of breast carcinoma cells, in which Rab8 also acts via regulation of membrane trafficking.
      Title: Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.
    4. A single nucleotide polymorphisms (SNPs) associated with higher delta-6 desaturase (D6D) activity within the Rho guanine nucleotide exchange factor 10 (ARHGEF10) gene is potentially altering plasma triglyceride levels.
      Title: A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia.
    5. Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8.
      Title: ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.
    6. This study provided new insights into the roles of ARHGEF10 SNPs rs2280887, rs9657362, and rs4480162 in the development and progression of ischemic stroke in northern Chinese Han population.
      Title: ARHGEF10 gene polymorphism is closely associated with the risk of ischemic stroke in Northern Han Chinese population.
    7. A significant association of ARHGEF10 with paclitaxel chemotherapy induced peripheral neuropathy was found.
      Title: Association of the Charcot-Marie-Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance).
    8. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).
      Title: Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).
    9. the rs4376531 polymorphism in the ARHGEF10 gene is a risk factor for atherothrombotic stroke in the Han Chinese population
      Title: The functional SNP rs4376531 in the ARHGEF gene is a risk factor for the atherothrombotic stroke in Han Chinese.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Autosomal dominant slowed nerve conduction velocity
    MedGen: C1842357 OMIM: 608236 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of brain lesion distribution in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study of selenium concentrations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC131664, DKFZp686H0726

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myelination in peripheral nervous system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 10
    Names
    Rho guanine nucleotide exchange factor (GEF) 10

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008480.1 RefSeqGene

      Range
      5001..139659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_234

    mRNA and Protein(s)

    1. NM_001308152.2 → NP_001295081.1  rho guanine nucleotide exchange factor 10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA758332, AB002292, AC019257, BC112926
      Consensus CDS
      CCDS78297.1
      UniProtKB/TrEMBL
      A0A2X0U4L4
      Related
      ENSP00000427909.1, ENST00000520359.5
      Conserved Domains (2) summary
      pfam00621
      Location:366 → 544
      RhoGEF; RhoGEF domain
      cl17171
      Location:576 → 640
      PH-like; Pleckstrin homology-like domain

    2. NM_001308153.2 → NP_001295082.1  rho guanine nucleotide exchange factor 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and contains an alternate exon in the 5' UTR and 5' coding region, which results in the use of an alternate start codon compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AA758332, AB002292, AC019257, BC112926, CR749570
      Consensus CDS
      CCDS78296.1
      UniProtKB/TrEMBL
      A0A2X0U4L4
      Related
      ENSP00000431012.1, ENST00000518288.5
      Conserved Domains (2) summary
      pfam00621
      Location:429 → 606
      RhoGEF; RhoGEF domain
      cl17171
      Location:638 → 702
      PH-like; Pleckstrin homology-like domain

    3. NM_014629.4 → NP_055444.2  rho guanine nucleotide exchange factor 10 isoform 1

      See identical proteins and their annotated locations for NP_055444.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AA758332, AB002292, AC019257, AI348138, CN307765
      Consensus CDS
      CCDS34794.1
      UniProtKB/TrEMBL
      A0A2X0U4L4
      Related
      ENSP00000340297.3, ENST00000349830.8
      Conserved Domains (2) summary
      pfam00621
      Location:404 → 582
      RhoGEF; RhoGEF domain
      cl17171
      Location:614 → 678
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      1823300..1958641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422457.1 → XP_047278413.1  rho guanine nucleotide exchange factor 10 isoform X10

      UniProtKB/TrEMBL
      A0A2X0U4L4

    2. XM_047422452.1 → XP_047278408.1  rho guanine nucleotide exchange factor 10 isoform X7

      UniProtKB/TrEMBL
      A0A2X0U4L4

    3. XM_047422450.1 → XP_047278406.1  rho guanine nucleotide exchange factor 10 isoform X4

      UniProtKB/TrEMBL
      A0A2X0U4L4

    4. XM_047422454.1 → XP_047278410.1  rho guanine nucleotide exchange factor 10 isoform X3

      UniProtKB/TrEMBL
      A0A2X0U4L4

    5. XM_047422456.1 → XP_047278412.1  rho guanine nucleotide exchange factor 10 isoform X9

      UniProtKB/TrEMBL
      A0A2X0U4L4

    6. XM_047422461.1 → XP_047278417.1  rho guanine nucleotide exchange factor 10 isoform X15

      UniProtKB/TrEMBL
      A0A2X0U4L4

    7. XM_005266041.5 → XP_005266098.1  rho guanine nucleotide exchange factor 10 isoform X4

      See identical proteins and their annotated locations for XP_005266098.1

      UniProtKB/TrEMBL
      A0A2X0U4L4
      Conserved Domains (3) summary
      cd00160
      Location:398 → 582
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      PTZ00441
      Location:3 → 250
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cl17171
      Location:615 → 679
      PH-like; Pleckstrin homology-like domain

    8. XM_047422459.1 → XP_047278415.1  rho guanine nucleotide exchange factor 10 isoform X12

      UniProtKB/TrEMBL
      A0A2X0U4L4

    9. XM_047422455.1 → XP_047278411.1  rho guanine nucleotide exchange factor 10 isoform X9

      UniProtKB/TrEMBL
      A0A2X0U4L4

    10. XM_047422458.1 → XP_047278414.1  rho guanine nucleotide exchange factor 10 isoform X11

      UniProtKB/TrEMBL
      A0A2X0U4L4

    11. XM_017014003.2 → XP_016869492.1  rho guanine nucleotide exchange factor 10 isoform X2

      UniProtKB/Swiss-Prot
      O14665, O15013, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
      UniProtKB/TrEMBL
      A0A2X0U4L4
      Related
      ENSP00000381571.1, ENST00000398564.5
      Conserved Domains (2) summary
      pfam00621
      Location:429 → 607
      RhoGEF; RhoGEF domain
      cl17171
      Location:639 → 703
      PH-like; Pleckstrin homology-like domain

    12. XM_047422449.1 → XP_047278405.1  rho guanine nucleotide exchange factor 10 isoform X3

      UniProtKB/TrEMBL
      A0A2X0U4L4

    13. XM_024447335.2 → XP_024303103.1  rho guanine nucleotide exchange factor 10 isoform X1

      UniProtKB/TrEMBL
      A0A2X0U4L4
      Conserved Domains (3) summary
      cd00160
      Location:426 → 610
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      PTZ00441
      Location:27 → 278
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cl17171
      Location:643 → 707
      PH-like; Pleckstrin homology-like domain

    14. XM_047422453.1 → XP_047278409.1  rho guanine nucleotide exchange factor 10 isoform X8

      UniProtKB/TrEMBL
      A0A2X0U4L4

    15. XM_011534768.1 → XP_011533070.1  rho guanine nucleotide exchange factor 10 isoform X6

      See identical proteins and their annotated locations for XP_011533070.1

      UniProtKB/TrEMBL
      A0A2X0U4L4
      Conserved Domains (2) summary
      pfam00621
      Location:405 → 583
      RhoGEF; RhoGEF domain
      cl17171
      Location:615 → 679
      PH-like; Pleckstrin homology-like domain

    16. XM_047422451.1 → XP_047278407.1  rho guanine nucleotide exchange factor 10 isoform X5

      UniProtKB/TrEMBL
      A0A2X0U4L4

    17. XM_011534770.3 → XP_011533072.1  rho guanine nucleotide exchange factor 10 isoform X13

      See identical proteins and their annotated locations for XP_011533072.1

      UniProtKB/TrEMBL
      A0A2X0U4L4
      Conserved Domains (2) summary
      pfam00621
      Location:405 → 583
      RhoGEF; RhoGEF domain
      cl17171
      Location:615 → 679
      PH-like; Pleckstrin homology-like domain

    18. XM_047422460.1 → XP_047278416.1  rho guanine nucleotide exchange factor 10 isoform X14

      UniProtKB/TrEMBL
      A0A2X0U4L4

    19. XM_047422462.1 → XP_047278418.1  rho guanine nucleotide exchange factor 10 isoform X16

      UniProtKB/TrEMBL
      H0YAN8
      Related
      ENSP00000427768.1, ENST00000522435.5

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187576.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      6676..142017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328834.1 → XP_054184809.1  rho guanine nucleotide exchange factor 10 isoform X10

      UniProtKB/TrEMBL
      A0A2X0U4L4

    2. XM_054328829.1 → XP_054184804.1  rho guanine nucleotide exchange factor 10 isoform X7

      UniProtKB/TrEMBL
      A0A2X0U4L4

    3. XM_054328826.1 → XP_054184801.1  rho guanine nucleotide exchange factor 10 isoform X4

      UniProtKB/TrEMBL
      A0A2X0U4L4

    4. XM_054328831.1 → XP_054184806.1  rho guanine nucleotide exchange factor 10 isoform X3

      UniProtKB/TrEMBL
      A0A2X0U4L4

    5. XM_054328833.1 → XP_054184808.1  rho guanine nucleotide exchange factor 10 isoform X9

      UniProtKB/TrEMBL
      A0A2X0U4L4

    6. XM_054328839.1 → XP_054184814.1  rho guanine nucleotide exchange factor 10 isoform X15

      UniProtKB/TrEMBL
      A0A2X0U4L4

    7. XM_054328825.1 → XP_054184800.1  rho guanine nucleotide exchange factor 10 isoform X4

      UniProtKB/TrEMBL
      A0A2X0U4L4

    8. XM_054328836.1 → XP_054184811.1  rho guanine nucleotide exchange factor 10 isoform X12

      UniProtKB/TrEMBL
      A0A2X0U4L4

    9. XM_054328832.1 → XP_054184807.1  rho guanine nucleotide exchange factor 10 isoform X9

      UniProtKB/TrEMBL
      A0A2X0U4L4

    10. XM_054328835.1 → XP_054184810.1  rho guanine nucleotide exchange factor 10 isoform X11

      UniProtKB/TrEMBL
      A0A2X0U4L4

    11. XM_054328823.1 → XP_054184798.1  rho guanine nucleotide exchange factor 10 isoform X2

      UniProtKB/Swiss-Prot
      O14665, O15013, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
      UniProtKB/TrEMBL
      A0A2X0U4L4

    12. XM_054328824.1 → XP_054184799.1  rho guanine nucleotide exchange factor 10 isoform X3

      UniProtKB/TrEMBL
      A0A2X0U4L4

    13. XM_054328822.1 → XP_054184797.1  rho guanine nucleotide exchange factor 10 isoform X1

      UniProtKB/TrEMBL
      A0A2X0U4L4

    14. XM_054328830.1 → XP_054184805.1  rho guanine nucleotide exchange factor 10 isoform X8

      UniProtKB/TrEMBL
      A0A2X0U4L4

    15. XM_054328828.1 → XP_054184803.1  rho guanine nucleotide exchange factor 10 isoform X6

      UniProtKB/TrEMBL
      A0A2X0U4L4

    16. XM_054328827.1 → XP_054184802.1  rho guanine nucleotide exchange factor 10 isoform X5

      UniProtKB/TrEMBL
      A0A2X0U4L4

    17. XM_054328837.1 → XP_054184812.1  rho guanine nucleotide exchange factor 10 isoform X13

      UniProtKB/TrEMBL
      A0A2X0U4L4

    18. XM_054328838.1 → XP_054184813.1  rho guanine nucleotide exchange factor 10 isoform X14

      UniProtKB/TrEMBL
      A0A2X0U4L4

    19. XM_054328840.1 → XP_054184815.1  rho guanine nucleotide exchange factor 10 isoform X16

      UniProtKB/TrEMBL
      H0YAN8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      1601800..1736745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361550.1 → XP_054217525.1  rho guanine nucleotide exchange factor 10 isoform X10

      UniProtKB/TrEMBL
      A0A2X0U4L4

    2. XM_054361545.1 → XP_054217520.1  rho guanine nucleotide exchange factor 10 isoform X7

      UniProtKB/TrEMBL
      A0A2X0U4L4

    3. XM_054361542.1 → XP_054217517.1  rho guanine nucleotide exchange factor 10 isoform X4

      UniProtKB/TrEMBL
      A0A2X0U4L4

    4. XM_054361547.1 → XP_054217522.1  rho guanine nucleotide exchange factor 10 isoform X3

      UniProtKB/TrEMBL
      A0A2X0U4L4

    5. XM_054361549.1 → XP_054217524.1  rho guanine nucleotide exchange factor 10 isoform X9

      UniProtKB/TrEMBL
      A0A2X0U4L4

    6. XM_054361555.1 → XP_054217530.1  rho guanine nucleotide exchange factor 10 isoform X15

      UniProtKB/TrEMBL
      A0A2X0U4L4

    7. XM_054361541.1 → XP_054217516.1  rho guanine nucleotide exchange factor 10 isoform X4

      UniProtKB/TrEMBL
      A0A2X0U4L4

    8. XM_054361552.1 → XP_054217527.1  rho guanine nucleotide exchange factor 10 isoform X12

      UniProtKB/TrEMBL
      A0A2X0U4L4

    9. XM_054361548.1 → XP_054217523.1  rho guanine nucleotide exchange factor 10 isoform X9

      UniProtKB/TrEMBL
      A0A2X0U4L4

    10. XM_054361551.1 → XP_054217526.1  rho guanine nucleotide exchange factor 10 isoform X11

      UniProtKB/TrEMBL
      A0A2X0U4L4

    11. XM_054361539.1 → XP_054217514.1  rho guanine nucleotide exchange factor 10 isoform X2

      UniProtKB/Swiss-Prot
      O14665, O15013, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
      UniProtKB/TrEMBL
      A0A2X0U4L4

    12. XM_054361540.1 → XP_054217515.1  rho guanine nucleotide exchange factor 10 isoform X3

      UniProtKB/TrEMBL
      A0A2X0U4L4

    13. XM_054361538.1 → XP_054217513.1  rho guanine nucleotide exchange factor 10 isoform X1

      UniProtKB/TrEMBL
      A0A2X0U4L4

    14. XM_054361546.1 → XP_054217521.1  rho guanine nucleotide exchange factor 10 isoform X8

      UniProtKB/TrEMBL
      A0A2X0U4L4

    15. XM_054361544.1 → XP_054217519.1  rho guanine nucleotide exchange factor 10 isoform X6

      UniProtKB/TrEMBL
      A0A2X0U4L4

    16. XM_054361543.1 → XP_054217518.1  rho guanine nucleotide exchange factor 10 isoform X5

      UniProtKB/TrEMBL
      A0A2X0U4L4

    17. XM_054361553.1 → XP_054217528.1  rho guanine nucleotide exchange factor 10 isoform X13

      UniProtKB/TrEMBL
      A0A2X0U4L4

    18. XM_054361554.1 → XP_054217529.1  rho guanine nucleotide exchange factor 10 isoform X14

      UniProtKB/TrEMBL
      A0A2X0U4L4

    19. XM_054361556.1 → XP_054217531.1  rho guanine nucleotide exchange factor 10 isoform X16

      UniProtKB/TrEMBL
      H0YAN8

    RNA

    1. XR_008487897.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15013.4 GenPept UniProtKB/Swiss-Prot:O15013

    Gene LinkOut

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