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    SART3 spliceosome associated factor 3, U4/U6 recycling protein [ Homo sapiens (human) ]

    Gene ID: 9733, updated on 10-Dec-2024

    Summary

    Official Symbol
    SART3provided by HGNC
    Official Full Name
    spliceosome associated factor 3, U4/U6 recycling proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16860
    See related
    Ensembl:ENSG00000075856 MIM:611684; AllianceGenome:HGNC:16860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14
    Summary
    The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 12.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SART3 in Genome Data Viewer
    Location:
    12q23.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108522214..108561173, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108491579..108530540, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108915991..108954949, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1498 Neighboring gene MPRA-validated peak1935 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108906844-108907029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910488-108910988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910989-108911489 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:108918373-108919572 Neighboring gene FIC domain protein adenylyltransferase Neighboring gene MPRA-validated peak1936 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6969 Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108976096-108976273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108982554-108983282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108987423-108988089 Neighboring gene transmembrane protein 119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (824 hits/1289 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
    tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
    tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
    tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
    tat Tip110 binds to HIV-1 Tat and regulates Tat transactivation activity, suggesting an important role for Tip110 in HIV-1 gene expression and viral replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • KIAA0156, MGC138188

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of ASAP complex  
    located_in Cajal body PubMed 
    part_of U4/U6 snRNP PubMed 
    NOT part_of U4/U6 x U5 tri-snRNP complex PubMed 
    NOT part_of U4atac/U6atac snRNP PubMed 
    part_of U6atac snRNP PubMed 
    is_active_in cytoplasm  
    located_in nuclear speck  
    is_active_in nucleoplasm  
    located_in nucleoplasm PubMed 
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    squamous cell carcinoma antigen recognized by T-cells 3
    Names
    HIV-1 Tat-interacting protein of 110kDa
    PRP24 homolog
    SART-3
    hSART-3
    p110 nuclear RNA-binding protein
    squamous cell carcinoma antigen recognized by T cells 3
    tat-interacting protein of 110 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012155.2 RefSeqGene

      Range
      5217..44176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1285

    mRNA and Protein(s)

    1. NM_001410983.1 → NP_001397912.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC008119, AC010206
      Consensus CDS
      CCDS91747.1
      UniProtKB/TrEMBL
      A0A499FI31
      Related
      ENSP00000228284.4, ENST00000228284.8
    2. NM_014706.4 → NP_055521.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

      See identical proteins and their annotated locations for NP_055521.1

      Status: REVIEWED

      Source sequence(s)
      AI656011, BC032601, BQ231651, CN349201, D63879, DA391623
      Consensus CDS
      CCDS9117.1
      UniProtKB/Swiss-Prot
      A8K2E4, B7ZKM0, Q15020, Q2M2H0, Q58F06, Q8IUS1, Q96J95
      Related
      ENSP00000449386.2, ENST00000546815.6
      Conserved Domains (4) summary
      cd12391
      Location:705 → 778
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:799 → 879
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:877 → 933
      LSM_int_assoc; LSM-interacting associated unstructured
      cl26993
      Location:100 → 460
      Suf; Suppressor of forked protein (Suf)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      108522214..108561173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429916.1 → XP_047285872.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      108491579..108530540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373894.1 → XP_054229869.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

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