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    MAP7 microtubule associated protein 7 [ Homo sapiens (human) ]

    Gene ID: 9053, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MAP7provided by HGNC
    Official Full Name
    microtubule associated protein 7provided by HGNC
    Primary source
    HGNC:HGNC:6869
    See related
    Ensembl:ENSG00000135525 MIM:604108; AllianceGenome:HGNC:6869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMAP115; E-MAP-115
    Summary
    The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
    Expression
    Broad expression in kidney (RPKM 10.5), brain (RPKM 10.5) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAP7 in Genome Data Viewer
    Location:
    6q23.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (136342734..136550422, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (137530867..137738614, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (136663872..136871560, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:136609778-136610374 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:136610456-136611655 Neighboring gene uncharacterized LOC124901408 Neighboring gene BCL2 associated transcription factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:136655703-136656202 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 8 Neighboring gene MPRA-validated peak6144 silencer Neighboring gene phosphopantothenate--cysteine ligase-like Neighboring gene Sharpr-MPRA regulatory region 12163 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90214 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90217 Neighboring gene MPRA-validated peak6145 silencer Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 1 Neighboring gene MPRA-validated peak6146 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:136846904-136847714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:136870396-136870934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:136871473-136872010 Neighboring gene RN7SK pseudogene 299 Neighboring gene MPRA-validated peak6148 silencer Neighboring gene MAP7 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25115 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:136933733-136934303 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:136934304-136934873 Neighboring gene MAP3K5 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 219

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation. Masson D, et al. J Cell Biol, 1995 Nov. PMID 7490279, Free PMC Article
    2. A structural and dynamic visualization of the interaction between MAP7 and microtubules. Adler A, et al. Nat Commun, 2024 Mar 2. PMID 38431715, Free PMC Article
    3. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. Masson D, et al. J Cell Biol, 1993 Oct. PMID 8408219, Free PMC Article
    4. Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis. Sood R, et al. Cytogenet Genome Res, 2004. PMID 15218243
    5. Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. Fabre-Jonca N, et al. J Invest Dermatol, 1999 Feb. PMID 9989799

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A structural and dynamic visualization of the interaction between MAP7 and microtubules.
      Title: A structural and dynamic visualization of the interaction between MAP7 and microtubules.
    2. MAP7 Promotes Breast Cancer Cell Migration and Invasion by Regulating the NF-B Pathway.
      Title: MAP7 Promotes Breast Cancer Cell Migration and Invasion by Regulating the NF-B Pathway.
    3. Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid Leukemia Patients.
      Title: Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid Leukemia Patients.
    4. Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7.
      Title: Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7.
    5. Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis.
      Title: Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis.
    6. MAP7 interacts with RC3H1 and cooperatively regulate cell-cycle progression of cervical cancer cells via activating the NF-kappaB signaling.
      Title: MAP7 interacts with RC3H1 and cooperatively regulate cell-cycle progression of cervical cancer cells via activating the NF-κB signaling.
    7. MAP7 proteins are microtubule-tethered kinesin-1 activators, with which the motor transiently interacts as it moves along microtubules.
      Title: MAP7 family proteins regulate kinesin-1 recruitment and activation.
    8. Here we show that in HeLa cells, the paralogous MT-associated proteins Map7 and Map7D1 (Map7/7D1) form an interdependent regulatory loop with Disheveled, the critical signal transducer in Wnt signaling
      Title: Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling.
    9. findings demonstrate the efficacy of quantitative proteomics for identifying effector-host protein interactions and suggest that vesicular trafficking is a crucial cellular process that may be targeted by NleB1 and EspL through their interaction with ensconsin.
      Title: Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to osmotic stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ensconsin
    Names
    dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))
    epithelial microtubule-associated protein of 115 kDa

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198608.3 → NP_001185537.1  ensconsin isoform 1

      See identical proteins and their annotated locations for NP_001185537.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56455.1
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (1) summary
      pfam05672
      Location:483 → 641
      MAP7; MAP7 (E-MAP-115) family

    2. NM_001198609.2 → NP_001185538.1  ensconsin isoform 2

      See identical proteins and their annotated locations for NP_001185538.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS75527.1
      UniProtKB/TrEMBL
      A0A087WZ40, B7ZB64
      Related
      ENSP00000482335.1, ENST00000617204.4
      Conserved Domains (2) summary
      PTZ00108
      Location:101 → 317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:491 → 649
      MAP7; MAP7 (E-MAP-115) family

    3. NM_001198611.3 → NP_001185540.1  ensconsin isoform 4

      See identical proteins and their annotated locations for NP_001185540.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56454.1
      UniProtKB/TrEMBL
      B7ZB64
      Related
      ENSP00000400790.2, ENST00000438100.6
      Conserved Domains (3) summary
      PTZ00108
      Location:127 → 406
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam17380
      Location:87 → 173
      DUF5401; Family of unknown function (DUF5401)
      pfam05672
      Location:446 → 604
      MAP7; MAP7 (E-MAP-115) family

    4. NM_001198614.2 → NP_001185543.1  ensconsin isoform 1

      See identical proteins and their annotated locations for NP_001185543.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56455.1
      UniProtKB/TrEMBL
      B7ZB64
      Related
      ENSP00000414712.1, ENST00000454590.5
      Conserved Domains (1) summary
      pfam05672
      Location:483 → 641
      MAP7; MAP7 (E-MAP-115) family

    5. NM_001198615.3 → NP_001185544.1  ensconsin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL023284
      Consensus CDS
      CCDS56453.1
      UniProtKB/TrEMBL
      B2R704
      Related
      ENSP00000445737.1, ENST00000544465.5
      Conserved Domains (2) summary
      pfam05672
      Location:448 → 604
      MAP7; MAP7 (E-MAP-115) family
      pfam11262
      Location:69 → 141
      Tho2; Transcription factor/nuclear export subunit protein 2

    6. NM_001198616.3 → NP_001185545.1  ensconsin isoform 6

      See identical proteins and their annotated locations for NP_001185545.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      Consensus CDS
      CCDS75529.1
      UniProtKB/TrEMBL
      B2R704
      Related
      ENSP00000482356.1, ENST00000618822.4
      Conserved Domains (2) summary
      pfam05672
      Location:426 → 582
      MAP7; MAP7 (E-MAP-115) family
      pfam11262
      Location:84 → 156
      Tho2; Transcription factor/nuclear export subunit protein 2

    7. NM_001198617.3 → NP_001185546.1  ensconsin isoform 7

      See identical proteins and their annotated locations for NP_001185546.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      Consensus CDS
      CCDS75528.1
      UniProtKB/TrEMBL
      B2R704
      Related
      ENSP00000483511.1, ENST00000616617.4
      Conserved Domains (1) summary
      pfam05672
      Location:369 → 525
      MAP7; MAP7 (E-MAP-115) family

    8. NM_001198618.2 → NP_001185547.1  ensconsin isoform 8

      See identical proteins and their annotated locations for NP_001185547.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56452.1
      UniProtKB/TrEMBL
      B7Z3Y3
      Related
      ENSP00000414879.2, ENST00000432797.6
      Conserved Domains (1) summary
      pfam05672
      Location:315 → 473
      MAP7; MAP7 (E-MAP-115) family

    9. NM_001198619.2 → NP_001185548.1  ensconsin isoform 8

      See identical proteins and their annotated locations for NP_001185548.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56452.1
      UniProtKB/TrEMBL
      B7Z3Y3
      Related
      ENSP00000482998.1, ENST00000611373.1
      Conserved Domains (1) summary
      pfam05672
      Location:315 → 473
      MAP7; MAP7 (E-MAP-115) family

    10. NM_001388328.1 → NP_001375257.1  ensconsin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS75527.1
      UniProtKB/TrEMBL
      A0A087WZ40, B7ZB64
      Conserved Domains (2) summary
      PTZ00108
      Location:101 → 317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:491 → 649
      MAP7; MAP7 (E-MAP-115) family

    11. NM_001388329.1 → NP_001375258.1  ensconsin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS75527.1
      UniProtKB/TrEMBL
      A0A087WZ40, B7ZB64
      Conserved Domains (2) summary
      PTZ00108
      Location:101 → 317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:491 → 649
      MAP7; MAP7 (E-MAP-115) family

    12. NM_001388330.1 → NP_001375259.1  ensconsin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS75527.1
      UniProtKB/TrEMBL
      A0A087WZ40, B7ZB64
      Conserved Domains (2) summary
      PTZ00108
      Location:101 → 317
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:491 → 649
      MAP7; MAP7 (E-MAP-115) family

    13. NM_001388331.1 → NP_001375260.1  ensconsin isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (1) summary
      pfam05672
      Location:490 → 648
      MAP7; MAP7 (E-MAP-115) family

    14. NM_001388332.1 → NP_001375261.1  ensconsin isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56455.1
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (1) summary
      pfam05672
      Location:483 → 641
      MAP7; MAP7 (E-MAP-115) family

    15. NM_001388333.1 → NP_001375262.1  ensconsin isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56455.1
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (1) summary
      pfam05672
      Location:483 → 641
      MAP7; MAP7 (E-MAP-115) family

    16. NM_001388334.1 → NP_001375263.1  ensconsin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      UniProtKB/TrEMBL
      B2R704
      Conserved Domains (2) summary
      PTZ00108
      Location:79 → 295
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:469 → 627
      MAP7; MAP7 (E-MAP-115) family

    17. NM_001388335.1 → NP_001375264.1  ensconsin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      UniProtKB/TrEMBL
      B2R704
      Conserved Domains (1) summary
      pfam05672
      Location:468 → 626
      MAP7; MAP7 (E-MAP-115) family

    18. NM_001388336.1 → NP_001375265.1  ensconsin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (2) summary
      PTZ00108
      Location:127 → 414
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:454 → 612
      MAP7; MAP7 (E-MAP-115) family

    19. NM_001388337.1 → NP_001375266.1  ensconsin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (2) summary
      PTZ00108
      Location:127 → 414
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:454 → 612
      MAP7; MAP7 (E-MAP-115) family

    20. NM_001388338.1 → NP_001375267.1  ensconsin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (2) summary
      PTZ00108
      Location:127 → 414
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:454 → 612
      MAP7; MAP7 (E-MAP-115) family

    21. NM_001388339.1 → NP_001375268.1  ensconsin isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      UniProtKB/TrEMBL
      B2R704
      Conserved Domains (2) summary
      PTZ00108
      Location:105 → 384
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:424 → 605
      MAP7; MAP7 (E-MAP-115) family

    22. NM_001388340.1 → NP_001375269.1  ensconsin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56454.1
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (3) summary
      PTZ00108
      Location:127 → 406
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam17380
      Location:87 → 173
      DUF5401; Family of unknown function (DUF5401)
      pfam05672
      Location:446 → 604
      MAP7; MAP7 (E-MAP-115) family

    23. NM_001388341.1 → NP_001375270.1  ensconsin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56454.1
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (3) summary
      PTZ00108
      Location:127 → 406
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam17380
      Location:87 → 173
      DUF5401; Family of unknown function (DUF5401)
      pfam05672
      Location:446 → 604
      MAP7; MAP7 (E-MAP-115) family

    24. NM_001388342.1 → NP_001375271.1  ensconsin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      UniProtKB/TrEMBL
      B2R704
      Conserved Domains (2) summary
      PTZ00108
      Location:105 → 392
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:432 → 590
      MAP7; MAP7 (E-MAP-115) family

    25. NM_001388343.1 → NP_001375272.1  ensconsin isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (2) summary
      pfam17380
      Location:8 → 122
      DUF5401; Family of unknown function (DUF5401)
      pfam05672
      Location:424 → 582
      MAP7; MAP7 (E-MAP-115) family

    26. NM_001388344.1 → NP_001375273.1  ensconsin isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (2) summary
      PTZ00108
      Location:101 → 363
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam05672
      Location:403 → 561
      MAP7; MAP7 (E-MAP-115) family

    27. NM_001388345.1 → NP_001375274.1  ensconsin isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (1) summary
      pfam05672
      Location:352 → 510
      MAP7; MAP7 (E-MAP-115) family

    28. NM_001388346.1 → NP_001375275.1  ensconsin isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7ZB64
      Conserved Domains (1) summary
      pfam05672
      Location:352 → 510
      MAP7; MAP7 (E-MAP-115) family

    29. NM_001388347.1 → NP_001375276.1  ensconsin isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      UniProtKB/TrEMBL
      B2R704
      Conserved Domains (1) summary
      pfam05672
      Location:330 → 488
      MAP7; MAP7 (E-MAP-115) family

    30. NM_001388348.1 → NP_001375277.1  ensconsin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56452.1
      UniProtKB/TrEMBL
      B7Z3Y3
      Conserved Domains (1) summary
      pfam05672
      Location:315 → 473
      MAP7; MAP7 (E-MAP-115) family

    31. NM_001388349.1 → NP_001375278.1  ensconsin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Consensus CDS
      CCDS56452.1
      UniProtKB/TrEMBL
      B7Z3Y3
      Conserved Domains (1) summary
      pfam05672
      Location:315 → 473
      MAP7; MAP7 (E-MAP-115) family

    32. NM_001388350.1 → NP_001375279.1  ensconsin isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7Z3Y3
      Conserved Domains (1) summary
      pfam05672
      Location:278 → 436
      MAP7; MAP7 (E-MAP-115) family

    33. NM_001388351.1 → NP_001375280.1  ensconsin isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      UniProtKB/TrEMBL
      B7Z3Y3
      Conserved Domains (1) summary
      pfam05672
      Location:278 → 436
      MAP7; MAP7 (E-MAP-115) family

    34. NM_001388352.1 → NP_001375281.1  ensconsin isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      UniProtKB/TrEMBL
      B7Z3Y3
      Conserved Domains (1) summary
      pfam05672
      Location:233 → 391
      MAP7; MAP7 (E-MAP-115) family

    35. NM_001388353.1 → NP_001375282.1  ensconsin isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL133511
      Conserved Domains (1) summary
      pfam05672
      Location:330 → 366
      MAP7; MAP7 (E-MAP-115) family

    36. NM_003980.6 → NP_003971.1  ensconsin isoform 3

      See identical proteins and their annotated locations for NP_003971.1

      Status: REVIEWED

      Source sequence(s)
      AL023284, AL024508
      Consensus CDS
      CCDS5178.1
      UniProtKB/Swiss-Prot
      B7Z290, B7Z400, B7Z5S7, B7Z9U7, C9JPS0, E9PCP3, F5H1E2, Q14244, Q7Z6S0, Q8TAU5, Q9NY82, Q9NY83
      UniProtKB/TrEMBL
      B2R704
      Related
      ENSP00000346581.2, ENST00000354570.8
      Conserved Domains (2) summary
      pfam05672
      Location:463 → 619
      MAP7; MAP7 (E-MAP-115) family
      pfam11262
      Location:84 → 156
      Tho2; Transcription factor/nuclear export subunit protein 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      136342734..136550422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419515.1 → XP_047275471.1  ensconsin isoform X3

      UniProtKB/TrEMBL
      B2R704

    2. XM_011536246.3 → XP_011534548.1  ensconsin isoform X2

      UniProtKB/TrEMBL
      B2R704
      Conserved Domains (2) summary
      pfam05672
      Location:419 → 575
      MAP7; MAP7 (E-MAP-115) family
      pfam11262
      Location:69 → 141
      Tho2; Transcription factor/nuclear export subunit protein 2

    3. XM_011536243.3 → XP_011534545.1  ensconsin isoform X1

      UniProtKB/TrEMBL
      B2R704
      Conserved Domains (2) summary
      pfam05672
      Location:456 → 612
      MAP7; MAP7 (E-MAP-115) family
      pfam11262
      Location:69 → 141
      Tho2; Transcription factor/nuclear export subunit protein 2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      137530867..137738614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356743.1 → XP_054212718.1  ensconsin isoform X3

      UniProtKB/TrEMBL
      B2R704

    2. XM_054356742.1 → XP_054212717.1  ensconsin isoform X2

      UniProtKB/TrEMBL
      B2R704

    3. XM_054356741.1 → XP_054212716.1  ensconsin isoform X1

      UniProtKB/TrEMBL
      B2R704
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14244.1 GenPept UniProtKB/Swiss-Prot:Q14244

    Gene LinkOut

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