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    GPBAR1 G protein-coupled bile acid receptor 1 [ Homo sapiens (human) ]

    Gene ID: 151306, updated on 9-Dec-2024

    Summary

    Official Symbol
    GPBAR1provided by HGNC
    Official Full Name
    G protein-coupled bile acid receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:19680
    See related
    Ensembl:ENSG00000179921 MIM:610147; AllianceGenome:HGNC:19680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BG37; TGR5; M-BAR; GPCR19; GPR131
    Summary
    This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in gall bladder (RPKM 4.9), fat (RPKM 2.9) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPBAR1 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218259496..218263861)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218745197..218749562)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219124219..219128584)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928487 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:219081921-219082524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12312 Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene tRNA-Tyr (anticodon ATA) 1-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219126185-219126990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219133153-219134038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17118 Neighboring gene angio associated migratory cell protein Neighboring gene PNKD metallo-beta-lactamase domain containing Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene microRNA 6513

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC40597

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled bile acid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled bile acid receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled bile acid receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G-protein coupled bile acid receptor 1
    Names
    G-protein coupled bile acid receptor BG37
    G-protein coupled receptor GPCR19
    membrane bile acid receptor
    membrane-type receptor for bile acids

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077191.2NP_001070659.1  G-protein coupled bile acid receptor 1

      See identical proteins and their annotated locations for NP_001070659.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC021016, AK122660, BC033625
      Consensus CDS
      CCDS46515.1
      UniProtKB/Swiss-Prot
      B3KV35, Q8TDU6
      Related
      ENSP00000430886.1, ENST00000522678.5
      Conserved Domains (2) summary
      cd14964
      Location:4975
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:28284
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001077194.2NP_001070662.1  G-protein coupled bile acid receptor 1

      See identical proteins and their annotated locations for NP_001070662.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC021016, AK122660, BC033625, BI834364
      Consensus CDS
      CCDS46515.1
      UniProtKB/Swiss-Prot
      B3KV35, Q8TDU6
      Related
      ENSP00000428824.1, ENST00000521462.1
      Conserved Domains (2) summary
      cd14964
      Location:4975
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:28284
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_001321950.2NP_001308879.1  G-protein coupled bile acid receptor 1

      Status: REVIEWED

      Source sequence(s)
      AC021016, AK122658, BC033625
      Consensus CDS
      CCDS46515.1
      UniProtKB/Swiss-Prot
      B3KV35, Q8TDU6
      Related
      ENSP00000430698.1, ENST00000479077.5
      Conserved Domains (2) summary
      cd14964
      Location:4975
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:28284
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. NM_170699.3NP_733800.1  G-protein coupled bile acid receptor 1

      See identical proteins and their annotated locations for NP_733800.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC021016, AK122660, BC033625
      Consensus CDS
      CCDS46515.1
      UniProtKB/Swiss-Prot
      B3KV35, Q8TDU6
      Related
      ENSP00000430202.1, ENST00000519574.2
      Conserved Domains (2) summary
      cd14964
      Location:4975
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:28284
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218259496..218263861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510743.1XP_011509045.1  G-protein coupled bile acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_011509045.1

      UniProtKB/Swiss-Prot
      B3KV35, Q8TDU6
      Conserved Domains (2) summary
      cd14964
      Location:4975
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:28284
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      218745197..218749562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340779.1XP_054196754.1  G-protein coupled bile acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B3KV35, Q8TDU6