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    CXCR2 C-X-C motif chemokine receptor 2 [ Homo sapiens (human) ]

    Gene ID: 3579, updated on 9-Dec-2024

    Summary

    Official Symbol
    CXCR2provided by HGNC
    Official Full Name
    C-X-C motif chemokine receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:6027
    See related
    Ensembl:ENSG00000180871 MIM:146928; AllianceGenome:HGNC:6027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD182; IL8R2; IL8RA; IL8RB; CMKAR2; WHIMS2; CDw128b
    Summary
    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
    Expression
    Biased expression in appendix (RPKM 20.0), spleen (RPKM 13.2) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CXCR2 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218125294..218137251)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218610987..218622946)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218990017..219001974)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene uncharacterized LOC124907982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218890081-218890996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218896372-218896928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899047-218899580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899581-218900113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218910221-218910722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218930441-218930983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218933725-218934588 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218940751-218941252 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:219039587-219040086 Neighboring gene small nucleolar RNA U13 Neighboring gene C-X-C motif chemokine receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    WHIM syndrome 2
    MedGen: C5543622 OMIM: 619407 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef induces variable levels of CXCR2 downregulation in different cell types in an ubiquitin-independent manner PubMed
    capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed
    matrix gag HIV-1 MA interacts with CXCR2 in primary hepatocytes PubMed
    gag Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes upregulate the expression of CXCR2 receptor, which binds HIV-1 MA and its natural variant S75X, and enhances their internalization in cells PubMed
    gag HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway PubMed
    gag Treatment of human stellate cells with HIV-1 MA upregulates the expression of CXCR2, syndecan-2, collagen-I, alpha-SMA, vimentin, and endothelin-1 PubMed
    gag HIV-1 MA and SIV MA induce migration of CXCR2-expressing B cells and Jurkat cells PubMed
    gag Surface plasmon resonance (SPR) binding assay demonstrates that SIV MA binds CXCR2 with higher affinity than HIV-1 MA binds CXCR2 PubMed
    gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-X-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables interleukin-8 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables interleukin-8 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acute inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular defense response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in interleukin-8-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in metanephric tubule morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neutrophil apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutrophil activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mast cell granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 2
    Names
    CXC-R2
    CXCR-2
    CXCR2 gene for IL8 receptor type B
    GRO/MGSA receptor
    IL-8 receptor type 2
    IL-8R B
    chemokine (CXC) receptor 2
    high affinity interleukin-8 receptor B
    interleukin 8 receptor type 2
    interleukin 8 receptor, beta
    interleukin-8 receptor type B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052975.1 RefSeqGene

      Range
      5739..16962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168298.2NP_001161770.1  C-X-C chemokine receptor type 2

      See identical proteins and their annotated locations for NP_001161770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124768, AJ710879, DA674925
      Consensus CDS
      CCDS2408.1
      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Conserved Domains (1) summary
      cd15178
      Location:49325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001557.4NP_001548.1  C-X-C chemokine receptor type 2

      See identical proteins and their annotated locations for NP_001548.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124768, L19593
      Consensus CDS
      CCDS2408.1
      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Related
      ENSP00000319635.2, ENST00000318507.7
      Conserved Domains (1) summary
      cd15178
      Location:49325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218125294..218137251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444190.1XP_047300146.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    2. XM_047444189.1XP_047300145.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    3. XM_047444187.1XP_047300143.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    4. XM_047444191.1XP_047300147.1  C-X-C chemokine receptor type 2 isoform X2

    5. XM_005246530.4XP_005246587.1  C-X-C chemokine receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_005246587.1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Conserved Domains (1) summary
      cd15178
      Location:49325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. XM_047444188.1XP_047300144.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    7. XM_017003991.2XP_016859480.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Conserved Domains (1) summary
      cd15178
      Location:49325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      218610987..218622946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341825.1XP_054197800.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    2. XM_054341823.1XP_054197798.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    3. XM_054341824.1XP_054197799.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    4. XM_054341821.1XP_054197796.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    5. XM_054341826.1XP_054197801.1  C-X-C chemokine receptor type 2 isoform X2

    6. XM_054341822.1XP_054197797.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4