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    CEACAM1 CEA cell adhesion molecule 1 [ Homo sapiens (human) ]

    Gene ID: 634, updated on 4-Jan-2025

    Summary

    Official Symbol
    CEACAM1provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:1814
    See related
    Ensembl:ENSG00000079385 MIM:109770; AllianceGenome:HGNC:1814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BGP; BGP1; BGPI
    Summary
    This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
    Expression
    Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CEACAM1 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42507306..42528481, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45326710..45347884, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43011458..43032633, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIPE antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:42977425-42978405 Neighboring gene MPRA-validated peak3491 silencer Neighboring gene RNA, U4 small nuclear 60, pseudogene Neighboring gene AN1-type zinc finger protein 5-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14720 Neighboring gene uncharacterized LOC105372407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:43032933-43033795 Neighboring gene MPRA-validated peak3492 silencer Neighboring gene MPRA-validated peak3493 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43064131-43064631 Neighboring gene CEA cell adhesion molecule pseudogene 2 Neighboring gene CEA cell adhesion molecule 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding PubMed 
    enables bile acid transmembrane transporter activity  
    enables calmodulin binding  
    enables filamin binding PubMed 
    enables identical protein binding PubMed 
    enables identical protein binding PubMed 
    enables kinase binding PubMed 
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein homodimerization activity  
    enables protein phosphatase binding PubMed 
    enables protein tyrosine kinase binding  
    enables protein tyrosine kinase binding PubMed 
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in angiogenesis PubMed 
    involved_in bile acid and bile salt transport  
    involved_in blood vessel development  
    involved_in cell adhesion  
    involved_in cell migration PubMed 
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules  
    involved_in cellular response to insulin stimulus  
    involved_in common myeloid progenitor cell proliferation  
    involved_in granulocyte colony-stimulating factor signaling pathway  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules PubMed 
    involved_in insulin catabolic process  
    involved_in insulin receptor internalization  
    involved_in integrin-mediated signaling pathway PubMed 
    involved_in negative regulation of T cell mediated cytotoxicity PubMed 
    involved_in negative regulation of T cell receptor signaling pathway PubMed 
    involved_in negative regulation of cytotoxic T cell degranulation PubMed 
    involved_in negative regulation of fatty acid biosynthetic process  
    involved_in negative regulation of granulocyte differentiation  
    involved_in negative regulation of hepatocyte proliferation  
    involved_in negative regulation of interleukin-1 production  
    involved_in negative regulation of lipid biosynthetic process  
    involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target PubMed 
    involved_in negative regulation of platelet aggregation  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of vascular permeability  
    involved_in positive regulation of vasculogenesis  
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in regulation of blood vessel remodeling  
    involved_in regulation of cell growth  
    involved_in regulation of cell migration PubMed 
    involved_in regulation of endothelial cell differentiation  
    involved_in regulation of endothelial cell migration  
    involved_in regulation of epidermal growth factor receptor signaling pathway  
    involved_in regulation of homophilic cell adhesion  
    involved_in regulation of immune system process  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in regulation of sprouting angiogenesis  
    involved_in signal transduction  
    involved_in wound healing, spreading of cells PubMed 
    Items 1 - 25 of 40
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    part_of T cell receptor complex PubMed 
    located_in adherens junction  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in basal plasma membrane  
    located_in cell junction PubMed 
    located_in cell junction  
    is_active_in cell surface  
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cell-cell junction PubMed 
    located_in extracellular exosome PubMed 
    located_in lateral plasma membrane  
    located_in membrane PubMed 
    located_in microvillus membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in specific granule membrane  
    located_in tertiary granule membrane  
    located_in transport vesicle membrane  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    cell adhesion molecule CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1
    Names
    CD66a antigen
    antigen CD66
    carcinoembryonic antigen related cell adhesion molecule 1
    carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029051.2 RefSeqGene

      Range
      5029..26204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024912.3 → NP_001020083.1  cell adhesion molecule CEACAM1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001020083.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant has been referred to by multiple names, including BGPc, transmembrane carcinoembryonic antigen 3, TM3-CEA, and CEACAM1-4S.
      Source sequence(s)
      AC004785, BC014473, BC024164, DA432598, X16354
      Consensus CDS
      CCDS46089.1
      UniProtKB/TrEMBL
      Q3KRG8
      Related
      ENSP00000384709.3, ENST00000403444.7
      Conserved Domains (7) summary
      cd05740
      Location:146 → 233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      pfam07679
      Location:317 → 408
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      pfam15756
      Location:419 → 451
      DUF4690; Domain of unknown function (DUF4690)
      cl11960
      Location:340 → 415
      Ig; Immunoglobulin domain
    2. NM_001184813.2 → NP_001171742.1  cell adhesion molecule CEACAM1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001171742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1.
      Source sequence(s)
      AC004785, DA432598, X14831
      Consensus CDS
      CCDS54273.1
      UniProtKB/Swiss-Prot
      P13688
      Related
      ENSP00000244291.6, ENST00000352591.9
      Conserved Domains (4) summary
      cd05740
      Location:146 → 233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
    3. NM_001184815.2 → NP_001171744.1  cell adhesion molecule CEACAM1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001171744.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has one and lacks a different alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1. This variant has been referred to as 'alternative spliced isoform 3S' and 'short form 3'.
      Source sequence(s)
      AC004785, AK314211, M76743, X16354
      Consensus CDS
      CCDS54274.1
      UniProtKB/Swiss-Prot
      P13688
      Related
      ENSP00000351165.2, ENST00000358394.7
      Conserved Domains (4) summary
      cd05740
      Location:146 → 233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
    4. NM_001184816.2 → NP_001171745.1  cell adhesion molecule CEACAM1 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001171745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two coding region segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC004785, AY766113, DA432598, X16354
      Consensus CDS
      CCDS54272.1
      UniProtKB/Swiss-Prot
      P13688
      Related
      ENSP00000384083.1, ENST00000403461.5
      Conserved Domains (5) summary
      cd05740
      Location:146 → 233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      pfam15756
      Location:323 → 355
      DUF4690; Domain of unknown function (DUF4690)
    5. NM_001205344.2 → NP_001192273.1  cell adhesion molecule CEACAM1 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001192273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks a segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform 6) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL833584, BC014473, BU161659, DA432598, J03858, X14831
      UniProtKB/TrEMBL
      Q3KRG8
      Conserved Domains (4) summary
      cd05740
      Location:146 → 233
      Ig_CEACAM; Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:340 → 415
      Ig; Immunoglobulin domain
    6. NM_001712.5 → NP_001703.2  cell adhesion molecule CEACAM1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001703.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This variant has been referred to by multiple names, including transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and CEACAM1-4L.
      Source sequence(s)
      AC004785, DA432598, X16354
      Consensus CDS
      CCDS12609.1
      UniProtKB/Swiss-Prot
      A6NE38, A8MY49, O60430, P13688, Q069I7, Q13854, Q13857, Q13858, Q13859, Q13860, Q15600, Q15601, Q16170, Q5UB49, Q7KYP5, Q96CA7, Q9UQV9
      UniProtKB/TrEMBL
      Q3KRG8
      Related
      ENSP00000161559.6, ENST00000161559.11
      Conserved Domains (7) summary
      cd05740
      Location:146 → 233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      pfam07679
      Location:317 → 408
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      pfam15756
      Location:419 → 451
      DUF4690; Domain of unknown function (DUF4690)
      cl11960
      Location:340 → 415
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42507306..42528481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527206.3 → XP_011525508.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

      See identical proteins and their annotated locations for XP_011525508.1

      UniProtKB/Swiss-Prot
      P13688
      Conserved Domains (4) summary
      cd05740
      Location:146 → 233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157 → 233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45326710..45347884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321711.1 → XP_054177686.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

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