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    Fbxo31 F-box protein 31 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498959, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fbxo31provided by RGD
    Official Full Name
    F-box protein 31provided by RGD
    Primary source
    RGD:1561069
    See related
    EnsemblRapid:ENSRNOG00000042274 AllianceGenome:RGD:1561069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561069
    Summary
    Predicted to enable cyclin binding activity. Involved in positive regulation of dendrite morphogenesis and positive regulation of neuron migration. Located in centrosome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 45. Orthologous to human FBXO31 (F-box protein 31). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 122.2), Heart (RPKM 64.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fbxo31 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (66533437..66564674, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (49624813..49656052, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (53487610..53625673, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 16 open reading frame 95 Neighboring gene uncharacterized LOC120098534 Neighboring gene U4 spliceosomal RNA Neighboring gene transfer RNA methionine (anticodon CAU) 13 Neighboring gene microtubule-associated protein 1 light chain 3 beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC125122

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044259.3NP_001037724.2  F-box only protein 31 isoform 1

      See identical proteins and their annotated locations for NP_001037724.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      B2RYN2
      UniProtKB/TrEMBL
      A6IZP5
      Related
      ENSRNOP00000063581.2, ENSRNOT00000068764.5
      Conserved Domains (2) summary
      pfam12014
      Location:271329
      DUF3506; Domain of unknown function (DUF3506)
      pfam12937
      Location:6199
      F-box-like; F-box-like
    2. NM_001414926.1NP_001401855.1  F-box only protein 31 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8L2R3E7, A6IZP5
      Related
      ENSRNOP00000070481.2, ENSRNOT00000079651.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      66533437..66564674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)