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    Usp14 ubiquitin specific peptidase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291796, updated on 3-Dec-2024

    Summary

    Official Symbol
    Usp14provided by RGD
    Official Full Name
    ubiquitin specific peptidase 14provided by RGD
    Primary source
    RGD:1311825
    See related
    EnsemblRapid:ENSRNOG00000014981 AllianceGenome:RGD:1311825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Predicted to be involved in negative regulation of proteolysis involved in protein catabolic process; protein K48-linked deubiquitination; and regulation of chemotaxis. Predicted to act upstream of or within chemical synaptic transmission. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and cytosol. Predicted to be part of proteasome complex. Predicted to be active in glutamatergic synapse and presynaptic cytosol. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 487.9), Heart (RPKM 287.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Usp14 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1292745..1330867, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1018111..1057727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1178785..1216573, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component, pseudogene 2 Neighboring gene uncharacterized LOC134482897 Neighboring gene THO complex subunit 1 Neighboring gene NDUFA4, mitochondrial complex associated, pseudogene 2 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC95160

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 14
    Names
    ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
    ubiquitin specific protease 14
    NP_001008302.1
    XP_006254458.1
    XP_006254460.1
    XP_063133342.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008301.2NP_001008302.1  ubiquitin carboxyl-terminal hydrolase 14

      See identical proteins and their annotated locations for NP_001008302.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZY29, Q5U2N2
      Related
      ENSRNOP00000020537.7, ENSRNOT00000020537.8
      Conserved Domains (2) summary
      cd02657
      Location:106480
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:476
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      1292745..1330867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254396.4XP_006254458.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

      See identical proteins and their annotated locations for XP_006254458.1

      UniProtKB/TrEMBL
      A0A8I5ZY29, Q5U2N2
      Conserved Domains (2) summary
      cd02657
      Location:106480
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:476
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins
    2. XM_006254398.5XP_006254460.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZR30
      Related
      ENSRNOP00000069634.3, ENSRNOT00000084613.3
      Conserved Domains (2) summary
      cd02657
      Location:71445
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:465
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins
    3. XM_063277272.1XP_063133342.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZR30