Tet2 tet methylcytosine dioxygenase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tet2provided by RGD
Official Full Name: tet methylcytosine dioxygenase 2provided by RGD
Primary source: RGD:1311625
See related: EnsemblRapid:ENSRNOG00000023579 AllianceGenome:RGD:1311625
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311625
Summary: Predicted to enable 5-methylcytosine dioxygenase activity; ferrous iron binding activity; and zinc ion binding activity. Involved in response to organic cyclic compound. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 155.2), Muscle (RPKM 114.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (224662654..224746819, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (221988645..222072813, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (238719389..238802975, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression.
Title: C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression.

Submit: New GeneRIF Correction

General gene information

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Markers

BF399911 (e-PCR)
- UniSTS:247858

Tet2 (e-PCR), detects polymorphism
- UniSTS:531425

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5-methylcytosine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-methylcytosine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromosomal 5-methylcytosine DNA demethylation, oxidation pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosomal 5-methylcytosine DNA demethylation, oxidation pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytosine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemoglobin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in leukocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methylcytosine dioxygenase TET2

Names: probable methylcytosine dioxygenase TET2; tet oncogene family member 2

NP_001414486.1

EC 1.14.11.80

XP_006233409.1

EC 1.14.11.80

XP_008759756.1

EC 1.14.11.80

XP_063138035.1

EC 1.14.11.80

XP_063138036.1

EC 1.14.11.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.