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    Cuta cutA divalent cation tolerance homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294288, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cutaprovided by RGD
    Official Full Name
    cutA divalent cation tolerance homologprovided by RGD
    Primary source
    RGD:1303306
    See related
    EnsemblRapid:ENSRNOG00000000481 AllianceGenome:RGD:1303306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CutA1
    Summary
    Predicted to enable copper ion binding activity and enzyme binding activity. Involved in protein localization. Predicted to be located in membrane and mitochondrion. Orthologous to human CUTA (cutA divalent cation tolerance homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 94.3), Heart (RPKM 93.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cuta in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5024816..5026446, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5022956..5024580, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5532024..5533640, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene kinesin family member C1 Neighboring gene PHD finger protein 1 Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene zinc finger and BTB domain containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to metal ion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein CutA
    Names
    brain acetylcholinesterase putative membrane anchor
    divalent cation tolerant protein CUTA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164706.1NP_001158178.1  protein CutA isoform 2

      See identical proteins and their annotated locations for NP_001158178.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. Both variants 2 and 3 encode the same protein (isoform 2), which is shorter than isoform 1.
      Source sequence(s)
      BX883042, CB586341
      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A0A0G2JT00, A6JJJ6
      Conserved Domains (1) summary
      pfam03091
      Location:46141
      CutA1; CutA1 divalent ion tolerance protein
    2. NM_001164707.1NP_001158179.1  protein CutA isoform 2

      See identical proteins and their annotated locations for NP_001158179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. Both variants 2 and 3 encode the same protein (isoform 2), which is shorter than isoform 1.
      Source sequence(s)
      BP501235, BX883042, DV717217
      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A0A0G2JT00, A6JJJ6
      Conserved Domains (1) summary
      pfam03091
      Location:46141
      CutA1; CutA1 divalent ion tolerance protein
    3. NM_212494.2NP_997659.2  protein CutA isoform 1 precursor

      See identical proteins and their annotated locations for NP_997659.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BX883042
      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A6JJJ5, G3V616
      Related
      ENSRNOP00000000568.2, ENSRNOT00000000568.8
      Conserved Domains (1) summary
      pfam03091
      Location:69164
      CutA1; CutA1 divalent ion tolerance protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5024816..5026446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256120.5XP_006256182.1  protein CutA isoform X1

      See identical proteins and their annotated locations for XP_006256182.1

      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A6JJJ5, G3V616
      Conserved Domains (1) summary
      pfam03091
      Location:69164
      CutA1; CutA1 divalent ion tolerance protein

    RNA

    1. XR_005497189.2 RNA Sequence