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    Brix1 biogenesis of ribosomes BRX1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294799, updated on 9-Dec-2024

    Summary

    Official Symbol
    Brix1provided by RGD
    Official Full Name
    biogenesis of ribosomes BRX1provided by RGD
    Primary source
    RGD:1308508
    See related
    EnsemblRapid:ENSRNOG00000018021 AllianceGenome:RGD:1308508
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bxdc2; RGD1308508
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human BRIX1 (biogenesis of ribosomes BRX1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 122.2), Spleen (RPKM 97.2) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Brix1 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61177769..61188647, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59450608..59461486, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60450547..60461425, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene alanine-glyoxylate aminotransferase 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene mitochondrial ribosomal protein L40, pseudogene 1 Neighboring gene RAD1 checkpoint DNA exonuclease

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC116151

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosome biogenesis protein BRX1 homolog
    Names
    BRX1, biogenesis of ribosomes
    brix domain containing 2
    brix domain-containing protein 2
    ribosome biogenesis protein Brix

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029915.1NP_001025086.1  ribosome biogenesis protein BRX1 homolog

      See identical proteins and their annotated locations for NP_001025086.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098005
      UniProtKB/Swiss-Prot
      Q4QQT6
      UniProtKB/TrEMBL
      A0A8I6G7Z4, A6KJT1
      Related
      ENSRNOP00000082868.1, ENSRNOT00000118075.2
      Conserved Domains (1) summary
      cl00935
      Location:32306
      Brix; Brix domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      61177769..61188647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)