U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PATR-B major histocompatibility complex, class I, B [ Pan troglodytes (chimpanzee) ]

    Gene ID: 450202, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PATR-B
    Gene description
    major histocompatibility complex, class I, B
    See related
    Ensembl:ENSPTRG00000041261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    Papa-B; CHLA-B2; ChLA-B1; PATR-B16; PATR-B17
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PATR-B in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 5 NC_072403.2 (37242604..37247177, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 6 NC_072404.1 (37242611..37246370, complement)

    Chromosome 5 - NC_072403.2Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL3-like Neighboring gene uncharacterized LOC134810328 Neighboring gene dihydrofolate reductase-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Chimpanzee susceptibility to hepatitis C virus infection correlates with presence of Pt-KIR3DS2 and Pt-KIR2DL9: paired activating and inhibitory natural killer cell receptors. Abi-Rached L, et al. Immunogenetics, 2015 Oct. PMID 26260270, Free PMC Article
    2. Patr-A and B, the orthologues of HLA-A and B, present hepatitis C virus epitopes to CD8+ cytotoxic T cells from two chronically infected chimpanzees. Kowalski H, et al. J Exp Med, 1996 Apr 1. PMID 8666933, Free PMC Article
    3. A uniquely high level of recombination at the HLA-B locus. McAdam SN, et al. Proc Natl Acad Sci U S A, 1994 Jun 21. PMID 8016085, Free PMC Article
    4. Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune response and vaccination studies. Mizukoshi E, et al. J Virol, 2002 Jun. PMID 12021342, Free PMC Article
    5. Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes. Adams EJ, et al. Immunogenetics, 2000 May. PMID 10866107

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the compound genotype of homozygous C1 (+) Patr-B combined with either Pt-KIR3DS2 or Pt-KIR2DL9 is more strongly associated with HCV infection disease progression than either factor alone: [Pt-KIR3DS2 and Pt-KIR2DL9]
      Title: Chimpanzee susceptibility to hepatitis C virus infection correlates with presence of Pt-KIR3DS2 and Pt-KIR2DL9: paired activating and inhibitory natural killer cell receptors.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CHLA class I histocompatibility antigen, B-2 alpha chain
    Names
    CHLA class I histocompatibility antigen, B-1 alpha chain
    ChLa class I histocompatibility antigen, A-5 alpha chain
    MHC class I antigen
    Patr class I histocompatibility antigen, A-5 alpha chain
    class I histocompatibility antigen
    lymphocyte antigen
    major histocompatibility complex, class I, B 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009081.1 → NP_001009081.1  CHLA class I histocompatibility antigen, B-2 alpha chain precursor

      See identical proteins and their annotated locations for NP_001009081.1

      Status: PROVISIONAL

      Source sequence(s)
      X13116
      UniProtKB/Swiss-Prot
      P13751, P16210, Q9MXK0
      UniProtKB/TrEMBL
      A4Q9G6, G3GN10
      Related
      ENSPTRP00000061016.1, ENSPTRT00000072427.2
      Conserved Domains (3) summary
      cd07698
      Location:207 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:25 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:346 → 362
      MHC_I_C; MHC_I C-terminus

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072403.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      37242604..37247177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024356939.3 → XP_024212707.2  CHLA class I histocompatibility antigen, B-2 alpha chain isoform X1

      UniProtKB/Swiss-Prot
      P13750
      UniProtKB/TrEMBL
      Q9MXJ9

    2. XM_063812289.1 → XP_063668359.1  CHLA class I histocompatibility antigen, B-2 alpha chain isoform X1

      UniProtKB/Swiss-Prot
      P13750
      UniProtKB/TrEMBL
      Q9MXJ9

    3. XM_054686689.2 → XP_054542664.1  CHLA class I histocompatibility antigen, B-2 alpha chain isoform X2

      UniProtKB/Swiss-Prot
      P13750
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13750.1 GenPept UniProtKB/Swiss-Prot:P13750
    P13751.1 GenPept UniProtKB/Swiss-Prot:P13751
    P16210.1 GenPept UniProtKB/Swiss-Prot:P16210

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials