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    Ints12 integrator complex subunit 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ints12provided by RGD
    Official Full Name
    integrator complex subunit 12provided by RGD
    Primary source
    RGD:1359136
    See related
    EnsemblRapid:ENSRNOG00000011844 AllianceGenome:RGD:1359136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Phf22
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS12 (integrator complex subunit 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 53.7), Thymus (RPKM 51.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ints12 in Genome Data Viewer
    Location:
    2q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (224265787..224283523)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221591761..221609497)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (238253114..238270722)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nephronectin Neighboring gene MTOR associated protein, eak-7 homolog, pseudogene 1 Neighboring gene uncharacterized LOC102548236 Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene uncharacterized LOC102546359 Neighboring gene inorganic pyrophosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94937

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 12
    Names
    PHD finger protein 22
    int12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007640.2 → NP_001007641.1  integrator complex subunit 12

      See identical proteins and their annotated locations for NP_001007641.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q68FR3
      UniProtKB/TrEMBL
      A6HVU5
      Related
      ENSRNOP00000016066.5, ENSRNOT00000016066.8
      Conserved Domains (1) summary
      cd15501
      Location:160 → 211
      PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      224265787..224283523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233320.5 → XP_006233382.1  integrator complex subunit 12 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHJ4
      Related
      ENSRNOP00000088831.1, ENSRNOT00000116296.2
      Conserved Domains (1) summary
      cd15501
      Location:166 → 217
      PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FR3.1 GenPept UniProtKB/Swiss-Prot:Q68FR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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