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    Usp9x ubiquitin specific peptidase 9, X-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363445, updated on 3-Dec-2024

    Summary

    Official Symbol
    Usp9xprovided by RGD
    Official Full Name
    ubiquitin specific peptidase 9, X-linkedprovided by RGD
    Primary source
    RGD:1560056
    See related
    EnsemblRapid:ENSRNOG00000003261 AllianceGenome:RGD:1560056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560056
    Summary
    Predicted to enable several functions, including co-SMAD binding activity; deubiquitinase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including DNA alkylation repair; protein deubiquitination; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; in utero embryonic development; and nervous system development. Predicted to be located in apical part of cell; cilium; and growth cone. Predicted to be active in several cellular components, including centrosome; cytosol; and postsynapse. Human ortholog(s) of this gene implicated in female-restricted syndromic X-linked intellectual disability 99 and non-syndromic X-linked intellectual disability 99. Orthologous to human USP9X (ubiquitin specific peptidase 9 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 544.8), Muscle (RPKM 539.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
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    Genomic context

    See Usp9x in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (12261633..12399780, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (9588825..9726993, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (10510033..10660555, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21 Neighboring gene uncharacterized LOC102547042 Neighboring gene ribosomal protein S19, pseudogene 3 Neighboring gene transfer RNA threonine (anticodon AGU) 31 Neighboring gene peptidylprolyl isomerase A, pseudogene 1 Neighboring gene ubiquitin-conjugating enzyme E2Q family member 2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K11-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA alkylation repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebellar cortex structural organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytosolic ciliogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hippocampus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoubiquitinated protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into peroxisome matrix, receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ubiquitin carboxyl-terminal hydrolase FAF-X
    Names
    ubiquitin specific peptidase 9, X chromosome
    NP_001129395.1
    XP_038955787.1
    XP_038955788.1
    XP_038955789.1
    XP_038955790.1
    XP_038955791.1
    XP_038955792.1
    XP_038955793.1
    XP_038955795.1
    XP_063136184.1
    XP_063136185.1
    XP_063136186.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135923.2NP_001129395.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 2

      See identical proteins and their annotated locations for NP_001129395.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Related
      ENSRNOP00000075990.3, ENSRNOT00000093067.3
      Conserved Domains (3) summary
      cd02659
      Location:15551958
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:20972476
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:900964
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. NM_001434267.1NP_001421196.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2K2C7, A6JZY9, D3ZC84

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      12261633..12399780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099861.2XP_038955789.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Conserved Domains (3) summary
      cd02659
      Location:15601963
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:21022481
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:905969
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_063280116.1XP_063136186.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X2

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
    3. XM_039099860.2XP_038955788.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Conserved Domains (3) summary
      cd02659
      Location:15601963
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:21022481
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:905969
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    4. XM_063280115.1XP_063136185.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
    5. XM_063280114.1XP_063136184.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
    6. XM_039099865.2XP_038955793.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Conserved Domains (3) summary
      cd02659
      Location:15551958
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:20972476
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:900964
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    7. XM_039099863.2XP_038955791.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X2

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Conserved Domains (3) summary
      cd02659
      Location:15551958
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:20972476
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:900964
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    8. XM_039099864.2XP_038955792.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X3

      Related
      ENSRNOP00000072190.2, ENSRNOT00000080651.3
      Conserved Domains (3) summary
      cd02659
      Location:15601963
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:21022481
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:905969
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    9. XM_039099859.2XP_038955787.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Conserved Domains (3) summary
      cd02659
      Location:15601963
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:21022481
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:905969
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    10. XM_039099862.2XP_038955790.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Conserved Domains (3) summary
      cd02659
      Location:15601963
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:21022481
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:905969
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    11. XM_039099867.1XP_038955795.1  probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4

      UniProtKB/TrEMBL
      A6JZY9, D3ZC84
      Conserved Domains (3) summary
      cd02659
      Location:15551958
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:20972476
      DUF3517; Domain of unknown function (DUF3517)
      cl28922
      Location:900964
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001135893.1: Suppressed sequence

      Description
      NM_001135893.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.