Cpd carboxypeptidase D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpdprovided by RGD
Official Full Name: carboxypeptidase Dprovided by RGD
Primary source: RGD:2393
See related: EnsemblRapid:ENSRNOG00000003873 AllianceGenome:RGD:2393
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein phosphatase 2A binding activity. Involved in cellular response to interleukin-2. Located in nucleus; perinuclear region of cytoplasm; and trans-Golgi network. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 473.7), Lung (RPKM 370.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (62121681..62185638, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (61623528..61687491, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (63325764..63389811)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The isolation and characterization of CPD from several haematopoietic tumour cells are reported.
Title: Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142190 (e-PCR)
- UniSTS:231440

D85391 (e-PCR)
- UniSTS:180258

D85391 (e-PCR)
- UniSTS:160123

AA960140 (e-PCR)
- UniSTS:160125

BE120708 (e-PCR)
- UniSTS:247423

STS-H01467 (e-PCR)
- UniSTS:14573

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase 2A binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-2	IEP Inferred from Expression Pattern more info	PubMed
involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carboxypeptidase D

Names: gp180; metallocarboxypeptidase D

NP_036968.1

EC 3.4.17.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012836.2 → NP_036968.1 carboxypeptidase D precursor

See identical proteins and their annotated locations for NP_036968.1

Status: PROVISIONAL

Source sequence(s)

U62897

UniProtKB/Swiss-Prot

O35850, Q9JHW1

UniProtKB/TrEMBL

F1LPC6

Related

ENSRNOP00000005262.3, ENSRNOT00000005262.7

Conserved Domains (4) summary

cd03863
Location:496 → 791

M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup

cd03868
Location:86 → 379

M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup

cd11308
Location:795 → 870

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cl11393
Location:930 → 1208

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins