Vmp1 vacuole membrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vmp1provided by RGD
Official Full Name: vacuole membrane protein 1provided by RGD
Primary source: RGD:70367
See related: EnsemblRapid:ENSRNOG00000003967 AllianceGenome:RGD:70367
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem49
Summary: Predicted to enable phospholipid scramblase activity. Involved in autophagy. Located in autophagosome membrane. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 235.8), Liver (RPKM 203.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (71903223..72002337, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (71405058..71505045, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (73901988..74001900, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
Title: Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
Pancreas beta cells trigger VMP1 expression and autophagy during the early cellular events in response to experimental diabetes.
Title: Autophagy and VMP1 expression are early cellular events in experimental diabetes.
VMP1 expression may be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis.
Title: VMP1 expression correlates with acinar cell cytoplasmic vacuolization in arginine-induced acute pancreatitis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Chm70 (e-PCR)
- UniSTS:518404

RH137097 (e-PCR)
- UniSTS:219185

AI787464 (e-PCR)
- UniSTS:165782

AA859070 (e-PCR)
- UniSTS:243867

BE110042 (e-PCR)
- UniSTS:245168

AU025309 (e-PCR)
- UniSTS:115389

D10Chm80 (e-PCR)
- UniSTS:518097

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phospholipid scramblase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome membrane docking	IEA Inferred from Electronic Annotation more info
involved_in autophagosome membrane docking	ISO Inferred from Sequence Orthology more info
involved_in autophagosome membrane docking	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	IEA Inferred from Electronic Annotation more info
involved_in cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISS Inferred from Sequence or Structural Similarity more info
involved_in organelle localization by membrane tethering	ISO Inferred from Sequence Orthology more info
involved_in organelle localization by membrane tethering	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in autophagosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vacuole membrane protein 1

Names: transmembrane protein 49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.