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    Ints1 integrator complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288514, updated on 9-Dec-2024

    Summary

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    Symbol
    Ints1provided by RGD
    Full Name
    integrator complex subunit 1provided by RGD
    Primary source
    RGD:1308908
    See related
    EnsemblRapid:ENSRNOG00000047880 AllianceGenome:RGD:1308908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308908
    Summary
    Predicted to be involved in snRNA processing. Predicted to act upstream of or within several processes, including U2 snRNA 3'-end processing; inner cell mass cell proliferation; and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleus. Predicted to be part of integrator complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 94.5), Adrenal (RPKM 70.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ints1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19975166..19999893)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14861312..14886048)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16950704..16974896)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 184A Neighboring gene uncharacterized LOC102546414 Neighboring gene MAF bZIP transcription factor K Neighboring gene MICAL-like 2 Neighboring gene uncharacterized LOC134481159

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death. Hata T, et al. Biochim Biophys Acta, 2007 Jul. PMID 17544522
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in U2 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within U2 snRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blastocyst growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 1; similar to KIAA1440 protein
    Names
    KIAA1440-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432127.1 → NP_001419056.1  similar to KIAA1440 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      D3ZIT7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19975166..19999893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089968.2 → XP_038945896.1  integrator complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      D3ZIT7, F1M8D7
      Conserved Domains (1) summary
      pfam12432
      Location:377 → 457
      DUF3677; Protein of unknown function (DUF3677)

    2. XM_063271732.1 → XP_063127802.1  integrator complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      D3ZIT7

    3. XM_063271733.1 → XP_063127803.1  integrator complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      D3ZIT7

    4. XM_039089970.2 → XP_038945898.1  integrator complex subunit 1 isoform X4

      Related
      ENSRNOP00000057113.6, ENSRNOT00000060370.6
      Conserved Domains (1) summary
      pfam12432
      Location:377 → 457
      DUF3677; Protein of unknown function (DUF3677)

    RNA

    1. XR_010056478.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials
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