Hey2 hes-related family bHLH transcription factor with YRPW motif 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hey2provided by RGD
Official Full Name: hes-related family bHLH transcription factor with YRPW motif 2provided by RGD
Primary source: RGD:621405
See related: EnsemblRapid:ENSRNOG00000013364 AllianceGenome:RGD:621405
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Herp1
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including Notch signaling pathway; negative regulation of cardiac vascular smooth muscle cell differentiation; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 71.5), Lung (RPKM 40.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (28641100..28651187)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (26822131..26832218)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (29191170..29201257)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p27kip1 has a role in transcriptional repression through Notch/HRT2 signaling in vascular smooth muscle cells
Title: A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in arterial endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within artery development	ISO Inferred from Sequence Orthology more info
involved_in ascending aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrial septum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within atrioventricular valve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac septum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac vascular smooth muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cochlea development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dorsal aorta morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocardial cushion to mesenchymal transition involved in heart valve formation	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart trabecula formation	ISO Inferred from Sequence Orthology more info
involved_in labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell development	ISO Inferred from Sequence Orthology more info
involved_in muscular septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biomineral tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac vascular smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-DNA complex assembly	ISO Inferred from Sequence Orthology more info
involved_in pulmonary artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tricuspid valve formation	ISO Inferred from Sequence Orthology more info
involved_in tricuspid valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in umbilical cord morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hairy/enhancer-of-split related with YRPW motif protein 2

Names: hairy/enhancer-of-split related with YRPW motif 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130417.1 → NP_569101.1 hairy/enhancer-of-split related with YRPW motif protein 2

See identical proteins and their annotated locations for NP_569101.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6JUS1, G3V7S6

Related

ENSRNOP00000018718.3, ENSRNOT00000018718.8

Conserved Domains (2) summary

smart00511
Location:120 → 165

ORANGE; Orange domain

cd00083
Location:49 → 105

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...