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    Rasl10b RAS-like, family 10, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303382, updated on 9-Dec-2024

    Summary

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    Symbol
    Rasl10bprovided by RGD
    Full Name
    RAS-like, family 10, member Bprovided by RGD
    Primary source
    RGD:1310873
    See related
    EnsemblRapid:ENSRNOG00000010302 AllianceGenome:RGD:1310873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Orthologous to human RASL10B (RAS like family 10 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 45.9), Heart (RPKM 27.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rasl10b in Genome Data Viewer
    Location:
    10q26
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68707315..68719642)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68209761..68222118)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70626227..70639072)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene adaptor related protein complex 2 subunit beta 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene growth arrest-specific 2 like 2 Neighboring gene similar to human chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Rybkin II, et al. J Cell Biol, 2007 Nov 5. PMID 17984325, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of peptide hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-like protein family member 10B
    Names
    ras-like protein family member 10B-like
    NP_001178577.1
    XP_006247090.1
    XP_006247091.1
    XP_008772032.1
    XP_063125158.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191648.1 → NP_001178577.1  ras-like protein family member 10B

      See identical proteins and their annotated locations for NP_001178577.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A096MKD2, A6HHH6
      Conserved Domains (1) summary
      cd04142
      Location:5 → 203
      RRP22; Ras-related protein on chromosome 22 (RRP22) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68707315..68719642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269088.1 → XP_063125158.1  ras-like protein family member 10B isoform X2

      UniProtKB/TrEMBL
      A0A096MKD2, A6HHH6
      Related
      ENSRNOP00000100565.1, ENSRNOT00000152884.1

    2. XM_006247029.5 → XP_006247091.1  ras-like protein family member 10B isoform X1

      See identical proteins and their annotated locations for XP_006247091.1

      UniProtKB/TrEMBL
      A0A8I6AHZ6, A6HHH6
      Conserved Domains (2) summary
      smart00173
      Location:5 → 207
      RAS; Ras subfamily of RAS small GTPases
      cl21455
      Location:5 → 235
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_006247028.5 → XP_006247090.1  ras-like protein family member 10B isoform X1

      See identical proteins and their annotated locations for XP_006247090.1

      UniProtKB/TrEMBL
      A0A8I6AHZ6, A6HHH6
      Related
      ENSRNOP00000092937.1, ENSRNOT00000117783.2
      Conserved Domains (2) summary
      smart00173
      Location:5 → 207
      RAS; Ras subfamily of RAS small GTPases
      cl21455
      Location:5 → 235
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_008773810.4 → XP_008772032.1  ras-like protein family member 10B isoform X3

      See identical proteins and their annotated locations for XP_008772032.1

      Conserved Domains (1) summary
      cl21455
      Location:50 → 181
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_010055184.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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