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    Cmbl carboxymethylenebutenolidase homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310201, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cmblprovided by RGD
    Official Full Name
    carboxymethylenebutenolidase homologprovided by RGD
    Primary source
    RGD:1306952
    See related
    EnsemblRapid:ENSRNOG00000011260 AllianceGenome:RGD:1306952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306952
    Summary
    Predicted to enable hydrolase activity. Predicted to be located in cytosol and membrane. Orthologous to human CMBL (carboxymethylenebutenolidase homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 460.9), Liver (RPKM 418.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cmbl in Genome Data Viewer
    Location:
    2q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (84280128..84301878)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (82569257..82591007)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (84645084..84666836)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC134485604 Neighboring gene chaperonin containing TCP1 subunit 5 Neighboring gene ATP synthase c subunit lysine N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95111

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxymethylenebutenolidase homolog
    Names
    Ab2-225
    carboxymethylenebutenolidase homolog (Pseudomonas)
    liver regeneration-related protein LRRG072
    NP_001008770.1
    XP_006232159.1
    XP_063137823.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008770.3 → NP_001008770.1  carboxymethylenebutenolidase homolog

      See identical proteins and their annotated locations for NP_001008770.1

      Status: VALIDATED

      Source sequence(s)
      BC088459, BF556107
      UniProtKB/Swiss-Prot
      Q7TP52
      UniProtKB/TrEMBL
      A6JMZ5
      Related
      ENSRNOP00000079112.2, ENSRNOT00000118086.2
      Conserved Domains (1) summary
      COG0412
      Location:21 → 244
      DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      84280128..84301878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232097.5 → XP_006232159.1  carboxymethylenebutenolidase homolog isoform X2

      See identical proteins and their annotated locations for XP_006232159.1

      UniProtKB/Swiss-Prot
      Q7TP52
      UniProtKB/TrEMBL
      A6JMZ5
      Conserved Domains (1) summary
      COG0412
      Location:21 → 244
      DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

    2. XM_063281753.1 → XP_063137823.1  carboxymethylenebutenolidase homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMF1
      Related
      ENSRNOP00000015448.5, ENSRNOT00000015448.9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TP52.1 GenPept UniProtKB/Swiss-Prot:Q7TP52

    Gene LinkOut

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