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    Foxr1 forkhead box R1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Foxr1provided by RGD
    Official Full Name
    forkhead box R1provided by RGD
    Primary source
    RGD:1309739
    See related
    EnsemblRapid:ENSRNOG00000029089 AllianceGenome:RGD:1309739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and sequence-specific double-stranded DNA binding activity. Predicted to be involved in brain development and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human FOXR1 (forkhead box R1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 6.6), Thymus (RPKM 2.7) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Foxr1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53657388..53669424, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44760587..44768696, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48754300..48762765, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene centrosomal AT-AC splicing factor Neighboring gene ribosomal protein s25 Neighboring gene methyltransferase like 9, pseudogene 1 Neighboring gene uroplakin 2 Neighboring gene BCL9 like Neighboring gene C-X-C motif chemokine receptor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein R1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429666.1 → NP_001416595.1  forkhead box protein R1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    2. NM_001429667.1 → NP_001416596.1  forkhead box protein R1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F1LTW6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53657388..53669424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242969.5 → XP_006243031.1  forkhead box protein R1 isoform X2

      Related
      ENSRNOP00000050539.7, ENSRNOT00000049125.7
      Conserved Domains (1) summary
      pfam00250
      Location:175 → 265
      Forkhead; Forkhead domain

    2. XM_006242968.5 → XP_006243030.1  forkhead box protein R1 isoform X1

      Related
      ENSRNOP00000112255.1, ENSRNOT00000122581.1
      Conserved Domains (1) summary
      pfam00250
      Location:175 → 265
      Forkhead; Forkhead domain

    3. XM_039082340.2 → XP_038938268.1  forkhead box protein R1 isoform X3

      Conserved Domains (1) summary
      cd20036
      Location:119 → 246
      FH_FOXR; Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily

    4. XM_039082343.2 → XP_038938271.1  forkhead box protein R1 isoform X5

    5. XM_039082342.2 → XP_038938270.1  forkhead box protein R1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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