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    LINC00115 long intergenic non-protein coding RNA 115 [ Homo sapiens (human) ]

    Gene ID: 79854, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00115provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 115provided by HGNC
    Primary source
    HGNC:HGNC:26211
    See related
    AllianceGenome:HGNC:26211
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00115
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    Genomic context

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    See LINC00115 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (826206..827522, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (255178..256494, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (761586..762902, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1409 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:726662-727228 Neighboring gene uncharacterized LOC124903817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2 Neighboring gene family with sequence similarity 87 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1 Neighboring gene long intergenic non-protein coding RNA 1128 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:772694-772873 Neighboring gene uncharacterized LOC107984850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:802261-802760 Neighboring gene family with sequence similarity 41 member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long intergenic non-protein coding RNA 115 (Linc00115): A notable oncogene in human malignancies. Xu Z, et al. Gene, 2024 Mar 1. PMID 38070791
    2. Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2). Ji F, et al. Bioengineered, 2022 Mar. PMID 35184643, Free PMC Article
    3. Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/β-catenin axis. Peng N, et al. J Cell Mol Med, 2021 Nov. PMID 34697900, Free PMC Article
    4. Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7. Yuan C, et al. FEBS Open Bio, 2020 Jul. PMID 32175684, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long intergenic non-protein coding RNA 115 (Linc00115): A notable oncogene in human malignancies.
      Title: Long intergenic non-protein coding RNA 115 (Linc00115): A notable oncogene in human malignancies.
    2. Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2).
      Title: Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2).
    3. Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/beta-catenin axis.
      Title: Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/β-catenin axis.
    4. Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7.
      Title: Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Clone Names

    • FLJ22639

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024321.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL669831

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      826206..827522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      255178..256494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024796.1: Suppressed sequence

      Description
      NM_024796.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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