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    Tgm5 transglutaminase 5 [ Mus musculus (house mouse) ]

    Gene ID: 74176, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tgm5provided by MGI
    Official Full Name
    transglutaminase 5provided by MGI
    Primary source
    MGI:MGI:1921426
    See related
    Ensembl:ENSMUSG00000053675 AllianceGenome:MGI:1921426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGx; TGMX; TGase-5; 2310007C07Rik
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in peeling skin syndrome 2. Orthologous to human TGM5 (transglutaminase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 1.0), cerebellum adult (RPKM 0.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tgm5 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120876591..120916322, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121046111..121085841, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cyclin D-type binding-protein 1 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene STARR-seq mESC enhancer starr_05521 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 7 Neighboring gene predicted gene, 23858

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice. Nakagawa N, et al. J Dermatol Sci, 2012 Mar. PMID 22258055
    2. Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life. Cangkrama M, et al. J Invest Dermatol, 2016 Jul. PMID 26975724
    3. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. Grenard P, et al. J Biol Chem, 2001 Aug 31. PMID 11390390
    4. ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Butera A, et al. Sci Adv, 2023 Apr 28. PMID 37115925, Free PMC Article
    5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143848, MGC143849

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase 5
    NP_001349653.1
    NP_083075.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362724.2 → NP_001349653.1  protein-glutamine gamma-glutamyltransferase 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844548
      Conserved Domains (2) summary
      smart00460
      Location:57 → 134
      TGc; Transglutaminase/protease-like homologues
      pfam00927
      Location:390 → 487
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    2. NM_028799.4 → NP_083075.1  protein-glutamine gamma-glutamyltransferase 5 isoform 1

      See identical proteins and their annotated locations for NP_083075.1

      Status: VALIDATED

      Source sequence(s)
      AL844548
      Consensus CDS
      CCDS16632.1
      UniProtKB/Swiss-Prot
      A2AQ62, Q3V1F9, Q9D7I9
      UniProtKB/TrEMBL
      Q14B90, Q14B91
      Related
      ENSMUSP00000028721.8, ENSMUST00000028721.8
      Conserved Domains (3) summary
      smart00460
      Location:275 → 368
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:11 → 126
      Transglut_N; Transglutaminase family
      pfam00927
      Location:624 → 721
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120876591..120916322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7I9.3 GenPept UniProtKB/Swiss-Prot:Q9D7I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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