Zfp24 zinc finger protein 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp24provided by MGI
Official Full Name: zinc finger protein 24provided by MGI
Primary source: MGI:MGI:1929704
See related: Ensembl:ENSMUSG00000051469 AllianceGenome:MGI:1929704
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KOX17; ZF-12; Znf24; Zfp191; 3526401F17Rik; 5033419P20Rik
Summary: Enables sequence-specific DNA binding activity. Involved in myelination. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb primordium; and sensory organ. Orthologous to human ZNF24 (zinc finger protein 24). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.8), CNS E14 (RPKM 4.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A2; 18 12.55 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (24142774..24155294, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (24009717..24020813, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZFP24 binds to a consensus DNA sequence in proximity to genes important for oligodendrocyte differentiation.
Title: Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation.
ZFP191 played an essential role in aggressive proliferation and migration of vascular smooth muscle cells, which in turn facilitated intimal hyperplasia.
Title: Zinc finger protein 191 deficiency attenuates vascular smooth muscle cell proliferation, migration, and intimal hyperplasia after endovascular arterial injury.
The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during lipopolysaccharide-induced endotoxic shock.
Title: Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice.
this study demonstrates that ZFP191 is required for the myelinating function of differentiated oligodendrocytes.
Title: ZFP191 is required by oligodendrocytes for CNS myelination.
Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage.
Title: Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors.
the DNA-binding domain of Zfp191 can specifically bind to the TCAT repeat motif, and there is a cooperative effect among the target DNA's multiple binding sites
Title: Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191.
These data show that Zfp191 is indispensable for early embryonic development and cell proliferation.
Title: The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI642085 (e-PCR)
- UniSTS:164631

Zfp191 (e-PCR), detects polymorphism
- UniSTS:265241

RH125544 (e-PCR)
- UniSTS:162359

Zfp191 (e-PCR), detects polymorphism
- UniSTS:508527

NoName (e-PCR)
- UniSTS:237752

Zfp191 (e-PCR), detects polymorphism
- UniSTS:525286

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 24

Names: hypomyelinated CNS protein; zfp-191; zinc finger protein 191; zinc finger protein ZF-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357447.1 → NP_001344376.1 zinc finger protein 24

Status: VALIDATED

Source sequence(s)

AC126807, BP764437

Consensus CDS

CCDS29098.1

UniProtKB/Swiss-Prot

Q5MDG8, Q91VN1, Q9WUQ0

Conserved Domains (3) summary

smart00431
Location:48 → 159

SCAN; leucine rich region

COG5048
Location:305 → 358

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:253 → 273

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001357448.1 → NP_001344377.1 zinc finger protein 24

Status: VALIDATED

Source sequence(s)

AC126807, BP764437

Consensus CDS

CCDS29098.1

UniProtKB/Swiss-Prot

Q5MDG8, Q91VN1, Q9WUQ0

Related

ENSMUSP00000122579.2, ENSMUST00000153337.2

Conserved Domains (3) summary

smart00431
Location:48 → 159

SCAN; leucine rich region

COG5048
Location:305 → 358

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:253 → 273

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_021559.3 → NP_067534.2 zinc finger protein 24

See identical proteins and their annotated locations for NP_067534.2

Status: VALIDATED

Source sequence(s)

AC126807, BC054832, BP764437, CD562306

Consensus CDS

CCDS29098.1

UniProtKB/Swiss-Prot

Q5MDG8, Q91VN1, Q9WUQ0

Related

ENSMUSP00000064637.6, ENSMUST00000066497.12

Conserved Domains (3) summary

smart00431
Location:48 → 159

SCAN; leucine rich region

COG5048
Location:305 → 358

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:253 → 273

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

24142774..24155294 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161225.1 → XP_036017118.1 zinc finger protein 24 isoform X1

UniProtKB/Swiss-Prot

Q5MDG8, Q91VN1, Q9WUQ0

Conserved Domains (3) summary

smart00431
Location:48 → 159

SCAN; leucine rich region

COG5048
Location:305 → 358

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:253 → 273

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036161226.1 → XP_036017119.1 zinc finger protein 24 isoform X1

UniProtKB/Swiss-Prot

Q5MDG8, Q91VN1, Q9WUQ0

Conserved Domains (3) summary

smart00431
Location:48 → 159

SCAN; leucine rich region

COG5048
Location:305 → 358

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:253 → 273

ZF_C2H2; C2H2 Zn finger [structural motif]