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    Gspt1 G1 to S phase transition 1 [ Mus musculus (house mouse) ]

    Gene ID: 14852, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Gspt1provided by MGI
    Official Full Name
    G1 to S phase transition 1provided by MGI
    Primary source
    MGI:MGI:1316728
    See related
    Ensembl:ENSMUSG00000062203 AllianceGenome:MGI:1316728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G1st; Gst-1
    Summary
    Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in regulation of translational termination and translational termination. Predicted to act upstream of or within protein methylation. Predicted to be part of translation release factor complex. Predicted to be active in cytosolic ribosome. Orthologous to human GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.1), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gspt1 in Genome Data Viewer
    Location:
    16 A1; 16 6.38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (11034104..11072189, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11216240..11254325, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930509G22 gene Neighboring gene RIKEN cDNA 2610020C07 gene Neighboring gene Wdr45 like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7427 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8617 Neighboring gene predicted gene, 57631 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:11254345-11254532 Neighboring gene microRNA 1945 Neighboring gene STARR-seq mESC enhancer starr_40101 Neighboring gene tumor necrosis factor receptor superfamily, member 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. Hoshino S, et al. EMBO J, 1989 Dec 1. PMID 2511002, Free PMC Article
    2. Potential of GSPT1 as a novel target for glioblastoma therapy. Sasayama T, et al. Cell Death Dis, 2024 Aug 8. PMID 39117611, Free PMC Article
    3. A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury. Ishii T, et al. J Biol Chem, 2017 Jan 27. PMID 27941025, Free PMC Article
    4. In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3. Alkalaeva EZ, et al. Cell, 2006 Jun 16. PMID 16777602
    5. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. Hoshino S, et al. J Biol Chem, 1998 Aug 28. PMID 9712840

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36230, MGC36735

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation release factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    Names
    G1 to S phase transition protein 1 homolog
    G1 to phase transition 1
    G1-to-S transition GTP binding protein
    eRF3a
    eukaryotic peptide chain release factor subunit 3a
    eukaryotic polypeptide chain release factor 3
    guanine nucleotide regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130008.1 → NP_001123480.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2

      See identical proteins and their annotated locations for NP_001123480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in an internal exon, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AC087541, AK032059, AK148603, BB631229, CJ260597
      Consensus CDS
      CCDS49764.1
      UniProtKB/Swiss-Prot
      Q8R050
      UniProtKB/TrEMBL
      Q8CCV1
      Related
      ENSMUSP00000130583.2, ENSMUST00000167571.8
      Conserved Domains (5) summary
      cd01883
      Location:212 → 428
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:208 → 632
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:64 → 81
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:437 → 518
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:524 → 630
      eRF3_C_III; C-terminal domain of eRF3

    2. NM_146066.2 → NP_666178.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

      See identical proteins and their annotated locations for NP_666178.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC087541, AK148603, BB631229, CJ260597
      Consensus CDS
      CCDS27961.2
      UniProtKB/Swiss-Prot
      E9QK49, G3UWC0, O88179, Q8K2E1, Q8R050
      Related
      ENSMUSP00000078940.8, ENSMUST00000080030.14
      Conserved Domains (5) summary
      cd01883
      Location:213 → 429
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:209 → 633
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:64 → 81
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:438 → 519
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:525 → 631
      eRF3_C_III; C-terminal domain of eRF3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      11034104..11072189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R050.2 GenPept UniProtKB/Swiss-Prot:Q8R050

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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