Elk3 ELK3, member of ETS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elk3provided by MGI
Official Full Name: ELK3, member of ETS oncogene familyprovided by MGI
Primary source: MGI:MGI:101762
See related: Ensembl:ENSMUSG00000008398 AllianceGenome:MGI:101762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Erp; Net; Etrp; Sap-2; D430049E23Rik
Summary: Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within angiogenesis; regulation of DNA-templated transcription; and wound healing. Located in nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and heart. Used to study congenital chylothorax. Orthologous to human ELK3 (ETS transcription factor ELK3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 24.3), limb E14.5 (RPKM 16.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 48.04 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (93083277..93147021, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (93247415..93311159, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5.
Title: Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM(2.5).
The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
Title: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
Title: Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression.
Title: Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression.
Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling.
Title: Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition.
Elk3 has distinct roles in maintaining retinal artery integrity.
Title: Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.
coexpression of KLF4 led to repression of Elk-3 promoter activity
Title: Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.
ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density.
Title: Cell density-dependent nuclear accumulation of ELK3 is involved in suppression of PAI-1 expression.
Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
Title: Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles
Title: Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit43 (e-PCR), detects polymorphism
- UniSTS:126222

Elk3 (e-PCR), detects polymorphism
- UniSTS:547214

Z32815 (e-PCR)
- UniSTS:163485

Elk3 (e-PCR), detects polymorphism
- UniSTS:536520

Z32815 (e-PCR)
- UniSTS:125925

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables purine-rich negative regulatory element binding	IEA Inferred from Electronic Annotation more info
enables purine-rich negative regulatory element binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ETS domain-containing protein Elk-3

Names: ETS-domain protein ELK-3; ETS-related protein ERP; ETS-related protein NET

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282967.1 → NP_001269896.1 ETS domain-containing protein Elk-3 isoform Elk3d

See identical proteins and their annotated locations for NP_001269896.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks exon 3, but maintains the reading frame compared to variant 1. The resulting isoform (Elk3d) lacks an internal protein segment compared to isoform Elk3. Unlike isoform Elk3, this isoform is predominantly localized in the cytosol and has been shown to activate transcription (PMID:20304071).

Source sequence(s)

AC140379, AC161054

Consensus CDS

CCDS70097.1

UniProtKB/TrEMBL

G3UVW8

Related

ENSMUSP00000121754.2, ENSMUST00000151153.2

Conserved Domains (1) summary

smart00413
Location:5 → 69

ETS; erythroblast transformation specific domain
NM_001322265.1 → NP_001309194.1 ETS domain-containing protein Elk-3 isoform Elk3c

Status: VALIDATED

Description

Transcript Variant: This variant (3) is alternatively spliced at exon 3, which causes a frameshift compared to variant 1. The resulting isoform (Elk3c, also known as Net-c) is shorter, with a distinct C-terminus compared to isoform Elk3.

Source sequence(s)

AC140379, AC161054, AK052546

UniProtKB/TrEMBL

C7C6B3

Conserved Domains (1) summary

smart00413
Location:5 → 89

ETS; erythroblast transformation specific domain
NM_001322268.1 → NP_001309197.1 ETS domain-containing protein Elk-3 isoform Elk3b

Status: VALIDATED

Description

Transcript Variant: This variant (2) is alternatively spliced and lacks the mid-region of exon 3, which causes a frameshift compared to variant 1. The resulting isoform (Elk3b, also known as Net-b) is shorter, with a distinct C-terminus compared to isoform Elk3. Note, variant 2 is borderline nonsense-mediated mRNA decay (NMD) candidate; however, this variant-specific protein expression has been observed in vivo (PMID:9315625).

Source sequence(s)

AC140379, AC161054, AK052546

Consensus CDS

CCDS83749.1

UniProtKB/TrEMBL

C7C6B2, G3UVX2

Related

ENSMUSP00000122324.2, ENSMUST00000129827.8

Conserved Domains (1) summary

smart00413
Location:5 → 89

ETS; erythroblast transformation specific domain
NM_013508.2 → NP_038536.2 ETS domain-containing protein Elk-3 isoform Elk3

See identical proteins and their annotated locations for NP_038536.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (Elk3, also known as Net). This isoform is predominantly localized in the nucleus and has been shown to inhibit transcription (PMID:20304071).

Source sequence(s)

AC140379, AC161054, AK052546

Consensus CDS

CCDS24124.1

UniProtKB/Swiss-Prot

P41971, P97747, Q62346, Q8BWH1

UniProtKB/TrEMBL

Q3UZH4

Related

ENSMUSP00000008542.6, ENSMUST00000008542.12

Conserved Domains (1) summary

smart00413
Location:5 → 89

ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

93083277..93147021 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244871.2 → XP_030100731.1 ETS domain-containing protein Elk-3 isoform X1

UniProtKB/Swiss-Prot

P41971, P97747, Q62346, Q8BWH1

UniProtKB/TrEMBL

Q3UZH4

Conserved Domains (1) summary

smart00413
Location:5 → 89

ETS; erythroblast transformation specific domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_205536.1: Suppressed sequence

Description

NM_205536.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.