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    Acaa1a acetyl-Coenzyme A acyltransferase 1A [ Mus musculus (house mouse) ]

    Gene ID: 113868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acaa1aprovided by MGI
    Official Full Name
    acetyl-Coenzyme A acyltransferase 1Aprovided by MGI
    Primary source
    MGI:MGI:2148491
    See related
    Ensembl:ENSMUSG00000036138 AllianceGenome:MGI:2148491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTL; Acaa; Acaa1; D9Ertd25e
    Summary
    Predicted to enable C-acyltransferase activity; acetate CoA-transferase activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in monocarboxylic acid metabolic process; response to nutrient; and response to steroid hormone. Predicted to act upstream of or within fatty acid metabolic process. Located in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 294.0), liver adult (RPKM 221.7) and 26 other tissues See more
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    Genomic context

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    See Acaa1a in Genome Data Viewer
    Location:
    9 F3; 9 71.33 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119170113..119179361)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119341028..119350296)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene oxidative-stress responsive 1 Neighboring gene STARR-positive B cell enhancer ABC_E1119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119231914-119232305 Neighboring gene STARR-positive B cell enhancer ABC_E11425 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene predicted gene, 53515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Luo R, et al. Signal Transduct Target Ther, 2021 Aug 31. PMID 34465723, Free PMC Article
    2. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Chevillard G, et al. Biochimie, 2004 Nov. PMID 15589695
    3. Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes. Chevillard G, et al. BMC Biochem, 2004 Mar 25. PMID 15043762, Free PMC Article
    4. Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. Cook WS, et al. Exp Cell Res, 2001 Aug 1. PMID 11461119
    5. Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Huyghe S, et al. Biochem J, 2001 Feb 1. PMID 11171065, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-beta pathology and cognitive decline.
      Title: A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline.
    2. Molecular cloning, gene structure and tissue distribution of 3-ketoacyl-CoA thiolase A.
      Title: Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7090

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetate CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyl-CoA C-acetyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables acetyl-CoA C-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA C-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyl-CoA C-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acetyl-CoA C-myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyl-CoA C-myristoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables palmitoyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-ketoacyl-CoA thiolase A, peroxisomal
    Names
    acetyl-CoA C-myristoyltransferase
    acetyl-CoA acyltransferase A
    beta-ketothiolase A
    peroxisomal 3-ketoacyl-CoA thiolase
    peroxisomal 3-oxoacyl-CoA thiolase A
    peroxisomal 3-oxoacyl-Coenzyme A thiolase
    thiolase A
    NP_001344445.1
    NP_001408349.1
    NP_570934.1
    XP_030099878.1
    XP_030099879.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357516.1 → NP_001344445.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC128702
      UniProtKB/TrEMBL
      Q8BLD7
      Conserved Domains (1) summary
      cl27751
      Location:1 → 268
      Thiolase_N; Thiolase, N-terminal domain

    2. NM_001421420.1 → NP_001408349.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC128702
      UniProtKB/Swiss-Prot
      Q921H8
      UniProtKB/TrEMBL
      Q3UPU8

    3. NM_130864.3 → NP_570934.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 precursor

      See identical proteins and their annotated locations for NP_570934.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC128702
      Consensus CDS
      CCDS23613.1
      UniProtKB/Swiss-Prot
      Q921H8
      UniProtKB/TrEMBL
      Q3UPU8
      Related
      ENSMUSP00000042351.6, ENSMUST00000039784.12
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 420
      PLN02287; 3-ketoacyl-CoA thiolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119170113..119179361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244019.2 → XP_030099879.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

      UniProtKB/Swiss-Prot
      Q921H8
      UniProtKB/TrEMBL
      Q3UPU8
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 420
      PLN02287; 3-ketoacyl-CoA thiolase

    2. XM_030244018.2 → XP_030099878.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

      UniProtKB/Swiss-Prot
      Q921H8
      UniProtKB/TrEMBL
      Q3UPU8
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 420
      PLN02287; 3-ketoacyl-CoA thiolase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921H8.1 GenPept UniProtKB/Swiss-Prot:Q921H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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