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    Krt14 keratin 14 [ Mus musculus (house mouse) ]

    Gene ID: 16664, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Krt14provided by MGI
    Official Full Name
    keratin 14provided by MGI
    Primary source
    MGI:MGI:96688
    See related
    Ensembl:ENSMUSG00000045545 AllianceGenome:MGI:96688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K14; CK-14; Krt1-14; Krt-1.14
    Summary
    This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in stomach adult (RPKM 89.1), limb E14.5 (RPKM 80.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krt14 in Genome Data Viewer
    Location:
    11 63.43 cM; 11 D
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100093988..100098336, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100203162..100207510, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39022 Neighboring gene keratin 9 Neighboring gene STARR-seq mESC enhancer starr_30714 Neighboring gene type I keratin KA11P Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX. Labudová M, et al. Acta Virol, 2019. PMID 31230446
    2. Clinical, pathological and immunological features of psoriatic-like lesions affecting keratin 14-vascular endothelial growth factor transgenic mice. Canavese M, et al. Histol Histopathol, 2011 Mar. PMID 21210341
    3. An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy. Cao T, et al. J Cell Biol, 2001 Feb 5. PMID 11157990, Free PMC Article
    4. A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes. Feng X, et al. J Cell Biol, 2015 Apr 13. PMID 25869667, Free PMC Article
    5. beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation. Teulière J, et al. Mol Cell Biol, 2004 Oct. PMID 15367683, Free PMC Article

    See all (599) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.
      Title: In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.
    2. Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
      Title: Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
    3. Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.
      Title: Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.
    4. Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3sigma and YAP1.
      Title: Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1.
    5. Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
      Title: Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
    6. keratin 1 (K1) is essential for the persistent infection caused by LCMV strain MX, and its absence very effectively slows down the course of infection
      Title: Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX.
    7. Cumulatively, these data indicate that altered CK14 (high) and CK18 (low) expression is perhaps an early event in bladder cancer tumorigenesis in females at least and is characteristic of both urothelial superficial pre-neoplastic and neoplastic lesions.
      Title: Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis.
    8. KRT14 is expressed in a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.
      Title: KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.
    9. CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14.
      Title: Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.
    10. RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling.
      Title: Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables keratin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables keratin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hair cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hair cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 14
    Names
    cytokeratin 14
    keratin complex 1, acidic, gene 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313956.1 → NP_001300885.1  keratin, type I cytoskeletal 14 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA050376, AA562488, AA612291, AI893364, AL590873
      Conserved Domains (2) summary
      pfam00038
      Location:120 → 370
      Filament; Intermediate filament protein
      cl19219
      Location:235 → 345
      DUF342; Protein of unknown function (DUF342)

    2. NM_001313957.1 → NP_001300886.1  keratin, type I cytoskeletal 14 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (3) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA499338, AA562488, AA612291, AA760592, AI893364, AL590873
      UniProtKB/Swiss-Prot
      Q61781
      Related
      ENSMUST00000137265.2
      Conserved Domains (1) summary
      pfam00038
      Location:1 → 214
      Filament; Intermediate filament protein

    3. NM_016958.2 → NP_058654.1  keratin, type I cytoskeletal 14 isoform 1

      See identical proteins and their annotated locations for NP_058654.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA499338, AA562488, AA612291, AA760592, AI893364, AL590873
      Consensus CDS
      CCDS25413.1
      UniProtKB/Swiss-Prot
      A2A4G4, Q61781, Q91VQ4, Q99LE0
      Related
      ENSMUSP00000007272.8, ENSMUST00000007272.8
      Conserved Domains (1) summary
      pfam00038
      Location:120 → 431
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100093988..100098336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61781.2 GenPept UniProtKB/Swiss-Prot:Q61781

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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