MED1 mediator complex subunit 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MED1provided by HGNC
Official Full Name: mediator complex subunit 1provided by HGNC
Primary source: HGNC:HGNC:9234
See related: Ensembl:ENSG00000125686 MIM:604311; AllianceGenome:HGNC:9234
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220
Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 8.1), appendix (RPKM 7.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (39404285..39451263, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (40268198..40315170, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (37560538..37607516, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8[+] T cell antitumor immunity.
Title: Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8(+) T cell antitumor immunity.
Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.
Title: Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.
MED1 induces M2 polarization of tumor-associated macrophages to aggravate breast cancer.
Title: MED1 induces M2 polarization of tumor-associated macrophages to aggravate breast cancer.
Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice.
Title: Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice.
Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome.
Title: Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome.
Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
Title: Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
Targeting cyclin-dependent kinase 7-association between CDK7 and pMED1 expression in prostate cancer tissue.
Title: Targeting cyclin-dependent kinase 7-association between CDK7 and pMED1 expression in prostate cancer tissue.
MED1 Downregulation Contributes to TGFbeta-Induced Metastasis by Inhibiting SMAD2 Ubiquitination Degradation in Cutaneous Melanoma.
Title: MED1 Downregulation Contributes to TGFβ-Induced Metastasis by Inhibiting SMAD2 Ubiquitination Degradation in Cutaneous Melanoma.
Phosphorylated MED1 links transcription recycling and cancer growth.
Title: Phosphorylated MED1 links transcription recycling and cancer growth.
Preparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure.
Title: Preparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
matrix	gag	HIV-1 MA upregulates MED1 mRNA expression in HepG2 cells	PubMed
	gag	HIV-1 MA upregulates MED1 gene expression in HepG2 cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79708 (e-PCR)
- UniSTS:88323

RH12583 (e-PCR)
- UniSTS:76569

MARC_12057-12058:1004548952:1 (e-PCR)
- UniSTS:267324

RH91484 (e-PCR)
- UniSTS:90451

PPARBP_2041 (e-PCR)
- UniSTS:280919

RH47206 (e-PCR)
- UniSTS:25444

RH64892 (e-PCR)
- UniSTS:38518

RH11014 (e-PCR)
- UniSTS:25290

HUEST-D29228 (e-PCR)
- UniSTS:25290

SGC32796 (e-PCR)
- UniSTS:12776

SHGC-36242 (e-PCR)
- UniSTS:5114

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables LBD domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables general transcription initiation factor binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear receptor coactivator activity	NAS Non-traceable Author Statement more info	PubMed
enables nuclear retinoic acid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear thyroid hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear thyroid hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear thyroid hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear vitamin D receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear vitamin D receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear vitamin D receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables nuclear vitamin D receptor binding	TAS Traceable Author Statement more info	PubMed
enables peroxisome proliferator activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G0 to G1 transition	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in androgen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hepatocyte growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to steroid hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to thyroid hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to thyroid hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic heart tube development	IEA Inferred from Electronic Annotation more info
involved_in embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in enucleate erythrocyte development	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation involved in mammary gland duct elongation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in lens development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland branching involved in pregnancy	IEA Inferred from Electronic Annotation more info
involved_in mammary gland branching involved in thelarche	IEA Inferred from Electronic Annotation more info
involved_in megakaryocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peroxisome proliferator activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G0 to G1 transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vitamin D receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in retinal pigment epithelium development	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular trabecula myocardium morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
part_of core mediator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 1

Names: ARC205; PPAR-binding protein; PPARG binding protein; TR-interacting protein 2; TRIP-2; activator-recruited cofactor 205 kDa component; p53 regulatory protein RB18A; peroxisome proliferator-activated receptor-binding protein; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; vitamin D receptor-interacting protein 230 kD; vitamin D receptor-interacting protein complex component DRIP205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046996.1 RefSeqGene

Range

5018..51996

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004774.4 → NP_004765.2 mediator of RNA polymerase II transcription subunit 1

See identical proteins and their annotated locations for NP_004765.2

Status: REVIEWED

Source sequence(s)

AC005288, BC131783, BP357374

Consensus CDS

CCDS11336.1

UniProtKB/Swiss-Prot

A2RRQ6, O43810, O75447, Q15648, Q6P9H7, Q6PK58, Q9HD39

UniProtKB/TrEMBL

B2RAG9

Related

ENSP00000300651.6, ENST00000300651.11

Conserved Domains (2) summary

PTZ00449
Location:942 → 1079

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

39404285..39451263 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006721957.3 → XP_006722020.1 mediator of RNA polymerase II transcription subunit 1 isoform X3

Related

ENSP00000377828.3, ENST00000394287.7

Conserved Domains (1) summary

pfam10744
Location:60 → 426

Med1; Mediator of RNA polymerase II transcription subunit 1
XM_047436314.1 → XP_047292270.1 mediator of RNA polymerase II transcription subunit 1 isoform X1

UniProtKB/TrEMBL

B4DSK7
XM_047436315.1 → XP_047292271.1 mediator of RNA polymerase II transcription subunit 1 isoform X2

UniProtKB/TrEMBL

B4DSK7

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

40268198..40315170 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316540.1 → XP_054172515.1 mediator of RNA polymerase II transcription subunit 1 isoform X3
XM_054316538.1 → XP_054172513.1 mediator of RNA polymerase II transcription subunit 1 isoform X1

UniProtKB/TrEMBL

B4DSK7
XM_054316539.1 → XP_054172514.1 mediator of RNA polymerase II transcription subunit 1 isoform X2

UniProtKB/TrEMBL

B4DSK7