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    PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102136293, updated on 3-Dec-2024

    Summary

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    Gene symbol
    PIK3C3
    Gene description
    phosphatidylinositol 3-kinase catalytic subunit type 3
    See related
    Ensembl:ENSMFAG00000003777
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3C3 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 18 NC_088392.1 (47758256..47894071, complement)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 18 NC_052272.1 (38696159..38913961, complement)

    Chromosome 18 - NC_088392.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 4 Neighboring gene Ras like without CAAX 2 Neighboring gene uncharacterized LOC102133752 Neighboring gene UPF0235 protein C15orf40-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in autophagy of peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase catalytic subunit type 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088392.1 Reference T2T-MFA8v1.0

      Range
      47758256..47894071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045377795.2 → XP_045233730.1  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2

      UniProtKB/TrEMBL
      A0A2K5WF49, G7PWP3
      Conserved Domains (3) summary
      cd08397
      Location:24 → 123
      C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
      cd00870
      Location:220 → 440
      PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
      cd00896
      Location:476 → 820
      PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

    2. XM_045377794.2 → XP_045233729.1  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

      UniProtKB/TrEMBL
      A0A2K5WEV7, G7PWP3
      Conserved Domains (3) summary
      cd08397
      Location:26 → 186
      C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
      cd00870
      Location:283 → 503
      PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
      cd00896
      Location:539 → 883
      PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase
    Nucleotide Protein
    Heading Accession and Version

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