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    TBK1 TANK binding kinase 1 [ Homo sapiens (human) ]

    Gene ID: 29110, updated on 10-Dec-2024

    Summary

    Official Symbol
    TBK1provided by HGNC
    Official Full Name
    TANK binding kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:11584
    See related
    Ensembl:ENSG00000183735 MIM:604834; AllianceGenome:HGNC:11584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAK; T2K; AIARV; IIAE8; FTDALS4
    Summary
    The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in testis (RPKM 15.8), bone marrow (RPKM 10.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TBK1 in Genome Data Viewer
    Location:
    12q14.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (64452120..64502114)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (64430747..64480735)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (64845900..64895894)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6592 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:64798894-64799770 Neighboring gene ribosomal protein S11 pseudogene 6 Neighboring gene exportin for tRNA Neighboring gene MPRA-validated peak1761 silencer Neighboring gene mitochondrial ribosomal protein S25 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6593 Neighboring gene uncharacterized LOC105369803 Neighboring gene Ras association domain family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6594 Neighboring gene small nucleolar RNA SNORD83

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif co-immunoprecipitates with TBK1 suggesting an interaction between Vif and TBK1 PubMed
    Vpr vpr HIV-1 Vpr co-immunoprecipitates with TBK1 suggesting an interaction between Vpr and TBK1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ11330

    Gene Ontology Provided by GOA

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables nucleic acid binding  
    enables phosphoprotein binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein phosphatase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 32
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in T follicular helper cell differentiation PubMed 
    involved_in activation of innate immune response  
    involved_in activation of innate immune response PubMed 
    involved_in antiviral innate immune response PubMed 
    involved_in cGAS/STING signaling pathway PubMed 
    involved_in canonical NF-kappaB signal transduction PubMed 
    involved_in chromatin remodeling  
    involved_in cytoplasmic pattern recognition receptor signaling pathway PubMed 
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to virus PubMed 
    involved_in dendritic cell proliferation  
    involved_in inflammatory response PubMed 
    involved_in innate immune response PubMed 
    involved_in innate immune response PubMed 
    involved_in macroautophagy  
    involved_in negative regulation of TORC1 signaling PubMed 
    involved_in negative regulation of gene expression  
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of TORC1 signaling PubMed 
    involved_in positive regulation of TORC2 signaling  
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of interferon-alpha production PubMed 
    involved_in positive regulation of interferon-beta production PubMed 
    involved_in positive regulation of macroautophagy PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of type I interferon production  
    involved_in positive regulation of type I interferon production PubMed 
    involved_in positive regulation of type I interferon production PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway  
    involved_in positive regulation of xenophagy  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of type I interferon production PubMed 
    involved_in response to virus PubMed 
    involved_in toll-like receptor 4 signaling pathway PubMed 
    involved_in type I interferon-mediated signaling pathway PubMed 
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytosol PubMed 
    is_active_in cytosol PubMed 
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    part_of serine/threonine protein kinase complex PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase TBK1
    Names
    NF-kB-activating kinase
    NF-kappa-B-activating kinase
    NP_037386.1
    XP_005268866.1
    XP_005268867.1
    XP_054227832.1
    XP_054227833.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046906.1 RefSeqGene

      Range
      5061..55055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1306

    mRNA and Protein(s)

    1. NM_013254.4 → NP_037386.1  serine/threonine-protein kinase TBK1

      See identical proteins and their annotated locations for NP_037386.1

      Status: REVIEWED

      Source sequence(s)
      AA970899, AC135279, AC136977, BC034950
      Consensus CDS
      CCDS8968.1
      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
      Related
      ENSP00000329967.5, ENST00000331710.10
      Conserved Domains (3) summary
      smart00220
      Location:9 → 242
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd12219
      Location:297 → 385
      UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
      cd13988
      Location:15 → 330
      STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      64452120..64502114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268810.2 → XP_005268867.1  serine/threonine-protein kinase TBK1 isoform X1

      See identical proteins and their annotated locations for XP_005268867.1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
      Conserved Domains (3) summary
      smart00220
      Location:9 → 242
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd12219
      Location:297 → 385
      UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
      cd13988
      Location:15 → 330
      STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1
    2. XM_005268809.2 → XP_005268866.1  serine/threonine-protein kinase TBK1 isoform X1

      See identical proteins and their annotated locations for XP_005268866.1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
      Conserved Domains (3) summary
      smart00220
      Location:9 → 242
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd12219
      Location:297 → 385
      UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
      cd13988
      Location:15 → 330
      STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

    RNA

    1. XR_007063071.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      64430747..64480735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371858.1 → XP_054227833.1  serine/threonine-protein kinase TBK1 isoform X1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
    2. XM_054371857.1 → XP_054227832.1  serine/threonine-protein kinase TBK1 isoform X1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646

    RNA

    1. XR_008488571.1 RNA Sequence

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