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    Nacad NAC alpha domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nacadprovided by RGD
    Official Full Name
    NAC alpha domain containingprovided by RGD
    Primary source
    RGD:1559824
    See related
    EnsemblRapid:ENSRNOG00000053875 AllianceGenome:RGD:1559824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Orthologous to human NACAD (NAC alpha domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 99.5), Heart (RPKM 19.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nacad in Genome Data Viewer
    Location:
    14q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85679215..85688742, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (81465299..81473866, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86860607..86868605, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547700 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene CCM2 scaffold protein Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene small nucleolar RNA SNORA5 Neighboring gene transforming growth factor beta regulator 4 Neighboring gene small nucleolar RNA, H/ACA box 5C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAC-alpha domain-containing protein 1
    NP_001094125.3
    XP_038947687.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100655.3 → NP_001094125.3  NAC-alpha domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      F1M6E5
      Related
      ENSRNOP00000105565.1, ENSRNOT00000166406.1
      Conserved Domains (4) summary
      PHA03247
      Location:594 → 1105
      PHA03247; large tegument protein UL36; Provisional
      PRK07994
      Location:630 → 758
      PRK07994; DNA polymerase III subunits gamma and tau; Validated
      cd14416
      Location:1375 → 1416
      UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
      cd22054
      Location:1280 → 1327
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      85679215..85688742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091759.2 → XP_038947687.1  NAC-alpha domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMB0
      Related
      ENSRNOP00000100754.1, ENSRNOT00000132648.1
      Conserved Domains (4) summary
      PHA03247
      Location:839 → 1385
      PHA03247; large tegument protein UL36; Provisional
      PRK14949
      Location:688 → 1044
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd14416
      Location:1655 → 1696
      UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
      cd22054
      Location:1560 → 1607
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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