Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp2r3aprovided by RGD
Official Full Name: protein phosphatase 2, regulatory subunit B'', alphaprovided by RGD
Primary source: RGD:1306958
See related: EnsemblRapid:ENSRNOG00000022999 AllianceGenome:RGD:1306958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein phosphatase regulator activity and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including regulation of canonical Wnt signaling pathway; regulation of cell migration involved in somitogenic axis elongation; and somitogenesis. Predicted to be part of protein phosphatase type 2A complex. Orthologous to human PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 410.0), Heart (RPKM 367.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (110582479..110720516, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (101703512..101841530, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (109481352..109621462, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potential mechanism of PPP2R3A in myocardial cells and its interacting proteins.
Title: The potential mechanism of PPP2R3A in myocardial cells and its interacting proteins.
Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension.
Title: Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142510 (e-PCR)
- UniSTS:231757

BE116212 (e-PCR)
- UniSTS:248453

RH137441 (e-PCR)
- UniSTS:219529

RH142615 (e-PCR)
- UniSTS:231862

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in eye photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration involved in somitogenic axis elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration involved in somitogenic axis elongation	ISO Inferred from Sequence Orthology more info
involved_in somatic muscle development	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic muscle development	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in somitogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Names: DNA for thyroid hormone receptor binding site (258bp); protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha

NP_001012202.2

EC 3.1.3.16

XP_006243695.1

EC 3.1.3.16

XP_006243696.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.