GIT2 GIT ArfGAP 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GIT2provided by HGNC
Official Full Name: GIT ArfGAP 2provided by HGNC
Primary source: HGNC:HGNC:4273
See related: Ensembl:ENSG00000139436 MIM:608564; AllianceGenome:HGNC:4273
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKL; CAT2; CAT-2
Summary: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Expression: Ubiquitous expression in spleen (RPKM 15.0), lymph node (RPKM 13.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (109929804..110000164, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (109905496..109975853, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (110367609..110434173, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
Title: Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.
Title: Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2.
GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cellsdagger.
Title: GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†.
our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases.
Title: The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.
we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease
Title: Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.
Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35.
Title: EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
Title: Nuclear GIT2 is an ATM substrate and promotes DNA repair.
ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine
Title: Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).
Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2.
Title: Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.
The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.
Title: Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of the metabolic syndrome in Indian Asian men. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G59127 (e-PCR)
- UniSTS:136448

G17616 (e-PCR)
- UniSTS:64000

PMC179881P3 (e-PCR)
- UniSTS:271664

D8S2279 (e-PCR)
- UniSTS:473907

RH78517 (e-PCR)
- UniSTS:46650

RH11171 (e-PCR)
- UniSTS:52567

L18426 (e-PCR)
- UniSTS:34648

RH25369 (e-PCR)
- UniSTS:88924

D12S1178E (e-PCR)
- UniSTS:21136

D12S161 (e-PCR)
- UniSTS:148901

RH104415 (e-PCR)
- UniSTS:98740

SHGC-144522 (e-PCR)
- UniSTS:174266

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ARF protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle recycling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in focal adhesion	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ARF GTPase-activating protein GIT2

Names: ARF GAP GIT2; G protein-coupled receptor kinase interacting ArfGAP 2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; Paxillin kinase linker; cool-associated, tyrosine phosphorylated protein 2; cool-interacting tyrosine-phosphorylated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029885.1 RefSeqGene

Range

5022..71586

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001135213.3 → NP_001128685.1 ARF GTPase-activating protein GIT2 isoform 6

See identical proteins and their annotated locations for NP_001128685.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two in-frame exons in the 3' coding region and includes an additional short in-frame exon in the central coding region, compared to isoform 1. The resulting isoform (6) is missing two internal fragments and includes a 2 residue insertion, compared to isoform 1.

Source sequence(s)

AA813937, BP871813, D63482

Consensus CDS

CCDS55884.1

UniProtKB/TrEMBL

R4GNG3

Related

ENSP00000391813.2, ENST00000457474.6

Conserved Domains (5) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:268 → 296

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:563 → 674

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)
NM_001135214.3 → NP_001128686.1 ARF GTPase-activating protein GIT2 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks one in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (5) is missing one fragment but has the same N- and C-termini as isoform 1.

Source sequence(s)

AA813937, AF124491, BP871813, CR749340, D63482

Consensus CDS

CCDS44968.1

UniProtKB/TrEMBL

R4GNG3

Related

ENSP00000354282.5, ENST00000361006.9

Conserved Domains (7) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:608 → 722

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 478

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
NM_001330153.2 → NP_001317082.1 ARF GTPase-activating protein GIT2 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (7) is shorter but has the same N- and C-termini as isoform 1.

Source sequence(s)

AA813937, AF124491, BE646544, BP871813, CR980157, D63482

Consensus CDS

CCDS81736.1

UniProtKB/TrEMBL

F8VXI9, R4GNG3

Related

ENSP00000448832.1, ENST00000551209.5

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:265 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:587 → 701

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
NM_001330154.2 → NP_001317083.1 ARF GTPase-activating protein GIT2 isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 8 is much shorter and has a different C-terminus than isoform 1.

Source sequence(s)

AC084876, AK222736, BM557270, BP871813

Consensus CDS

CCDS81737.1

UniProtKB/TrEMBL

B4E2E7, F8W822

Related

ENSP00000323833.9, ENST00000320063.10

Conserved Domains (4) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

pfam08518
Location:266 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT
NM_014776.5 → NP_055591.2 ARF GTPase-activating protein GIT2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two exons in the coding region, as compared to variant 1. Isoform 3 is missing two fragments but has the same N- and C-termini as isoform 1.

Source sequence(s)

AA813937, AF124491, BP871813, D63482

UniProtKB/TrEMBL

R4GNG3

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:558 → 672

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
NM_057169.5 → NP_476510.1 ARF GTPase-activating protein GIT2 isoform 1

See identical proteins and their annotated locations for NP_476510.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA813937, AF124491, BP871813, D63482

Consensus CDS

CCDS9138.1

UniProtKB/Swiss-Prot

Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2

UniProtKB/TrEMBL

R4GNG3

Related

ENSP00000347464.3, ENST00000355312.8

Conserved Domains (7) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:638 → 752

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 478

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
NM_057170.5 → NP_476511.1 ARF GTPase-activating protein GIT2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two exons and a portion of a third exon in the coding region, as compared to variant 1. The reading frame is maintained. Isoform 2 is missing internal 128 aa but has the same N- and C-termini as isoform 1.

Source sequence(s)

AA813937, AK308304, BC014223, BP871813, D63482

Consensus CDS

CCDS44969.1

UniProtKB/TrEMBL

R4GNG3

Related

ENSP00000447465.1, ENST00000553118.5

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

pfam08518
Location:266 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:510 → 624

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam16559
Location:414 → 450

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
NM_139201.3 → NP_631940.2 ARF GTPase-activating protein GIT2 isoform 4

See identical proteins and their annotated locations for NP_631940.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 4 is much shorter and has a different C-terminus than isoform 1.

Source sequence(s)

AC084876, AK222736, BM557270, BP871813

Consensus CDS

CCDS9139.1

UniProtKB/TrEMBL

B5BU58, Q6FI58

Related

ENSP00000450348.1, ENST00000547815.5

Conserved Domains (6) summary

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

cd08847
Location:1 → 111

ArfGap_GIT2; GIT2 GTPase activating protein for Arf

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 465

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

pfam14203
Location:246 → 284

TTRAP; Putative tranposon-transfer assisting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

109929804..110000164 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047429924.1 → XP_047285880.1 ARF GTPase-activating protein GIT2 isoform X8

UniProtKB/TrEMBL

R4GNG3
XM_047429926.1 → XP_047285882.1 ARF GTPase-activating protein GIT2 isoform X10

UniProtKB/TrEMBL

R4GNG3
XM_047429925.1 → XP_047285881.1 ARF GTPase-activating protein GIT2 isoform X9

UniProtKB/TrEMBL

R4GNG3
XM_017020258.3 → XP_016875747.1 ARF GTPase-activating protein GIT2 isoform X6

UniProtKB/TrEMBL

R4GNG3
XM_047429922.1 → XP_047285878.1 ARF GTPase-activating protein GIT2 isoform X3

UniProtKB/TrEMBL

R4GNG3
XM_047429923.1 → XP_047285879.1 ARF GTPase-activating protein GIT2 isoform X4

UniProtKB/TrEMBL

R4GNG3
XM_005253997.5 → XP_005254054.1 ARF GTPase-activating protein GIT2 isoform X1

UniProtKB/TrEMBL

R4GNG3

Conserved Domains (7) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:265 → 293

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:637 → 751

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:413 → 477

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
XM_006719712.5 → XP_006719775.1 ARF GTPase-activating protein GIT2 isoform X11

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:475 → 589

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
XM_006719709.5 → XP_006719772.1 ARF GTPase-activating protein GIT2 isoform X7

UniProtKB/TrEMBL

R4GNG3

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:588 → 702

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
XM_006719708.5 → XP_006719771.1 ARF GTPase-activating protein GIT2 isoform X5

UniProtKB/TrEMBL

R4GNG3

Conserved Domains (7) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:593 → 707

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 463

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
XM_006719707.5 → XP_006719770.1 ARF GTPase-activating protein GIT2 isoform X2

UniProtKB/TrEMBL

R4GNG3

Conserved Domains (7) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:623 → 737

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 463

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]
XM_047429928.1 → XP_047285884.1 ARF GTPase-activating protein GIT2 isoform X15

UniProtKB/TrEMBL

B4E2E7
XM_047429927.1 → XP_047285883.1 ARF GTPase-activating protein GIT2 isoform X14

UniProtKB/TrEMBL

B5BU58
XM_017020261.3 → XP_016875750.1 ARF GTPase-activating protein GIT2 isoform X12

UniProtKB/TrEMBL

B5BU58
XM_006719713.5 → XP_006719776.1 ARF GTPase-activating protein GIT2 isoform X13

UniProtKB/TrEMBL

B5BU58

Conserved Domains (6) summary

smart00105
Location:2 → 124

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:109 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:266 → 294

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12796
Location:137 → 229

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:414 → 449

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:137 → 165

ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

109905496..109975853 complement

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mRNA and Protein(s)

XM_054373915.1 → XP_054229890.1 ARF GTPase-activating protein GIT2 isoform X8

UniProtKB/TrEMBL

R4GNG3
XM_054373917.1 → XP_054229892.1 ARF GTPase-activating protein GIT2 isoform X10

UniProtKB/TrEMBL

R4GNG3
XM_054373916.1 → XP_054229891.1 ARF GTPase-activating protein GIT2 isoform X9

UniProtKB/TrEMBL

R4GNG3
XM_054373913.1 → XP_054229888.1 ARF GTPase-activating protein GIT2 isoform X6

UniProtKB/TrEMBL

R4GNG3
XM_054373910.1 → XP_054229885.1 ARF GTPase-activating protein GIT2 isoform X3

UniProtKB/TrEMBL

R4GNG3
XM_054373911.1 → XP_054229886.1 ARF GTPase-activating protein GIT2 isoform X4

UniProtKB/TrEMBL

R4GNG3
XM_054373908.1 → XP_054229883.1 ARF GTPase-activating protein GIT2 isoform X1

UniProtKB/TrEMBL

R4GNG3
XM_054373918.1 → XP_054229893.1 ARF GTPase-activating protein GIT2 isoform X11
XM_054373914.1 → XP_054229889.1 ARF GTPase-activating protein GIT2 isoform X7

UniProtKB/TrEMBL

R4GNG3
XM_054373912.1 → XP_054229887.1 ARF GTPase-activating protein GIT2 isoform X5

UniProtKB/TrEMBL

R4GNG3
XM_054373909.1 → XP_054229884.1 ARF GTPase-activating protein GIT2 isoform X2

UniProtKB/TrEMBL

R4GNG3
XM_054373922.1 → XP_054229897.1 ARF GTPase-activating protein GIT2 isoform X15

UniProtKB/TrEMBL

B4E2E7
XM_054373921.1 → XP_054229896.1 ARF GTPase-activating protein GIT2 isoform X14

UniProtKB/TrEMBL

B5BU58
XM_054373919.1 → XP_054229894.1 ARF GTPase-activating protein GIT2 isoform X12

UniProtKB/TrEMBL

B5BU58
XM_054373920.1 → XP_054229895.1 ARF GTPase-activating protein GIT2 isoform X13

UniProtKB/TrEMBL

B5BU58