ctp cut up [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ctpprovided by FlyBase
Official Full Name: cut upprovided by FlyBase
Primary source: FLYBASE:FBgn0011760
Locus tag: Dmel_CG6998
See related: AllianceGenome:FB:FBgn0011760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.128; Cdlc1; CG6998; Ctp; Ddlc-1; ddlc1; Ddlc1; DdlC1; dDYNLL1; dlc; Dlc; DLC8; Dmel\CG6998; l(1)G0153; l(1)G0204; l(1)G0207; l(1)G0244; l(1)G0248; l(1)G0338; l(1)G0371; l(1)G0387; l(1)G0432; l(1)G0445; LC8; lincRNA.S8635
Summary: Enables several functions, including disordered domain specific binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Involved in several processes, including cytoskeleton organization; germ cell development; and piRNA-mediated retrotransposon silencing by heterochromatin formation. Located in centriole and cytoplasm. Part of RNA polymerase II transcription repressor complex and cytoplasmic dynein complex. Is active in cytosol and nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval midgut primordium; ganglia; germline cell; and head epidermis primordium. Orthologous to several human genes including DYNLL2 (dynein light chain LC8-type 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4C13-4C14; 1-8 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4687800..4702034)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4581833..4596067)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ.
Title: Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ.
Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila.
Title: Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila.
Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila.
Title: Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila.
Genetic and biochemical analyses reveals that the Drosophila homolog of the LC8 dynein light chains (mammalian DYNLL1 and DYNLL2), called Cut up, binds proteasomes and functions specifically during their transport. These data support the model that Cut up functions to specify the dynein-mediated transport of neuronal proteasomes.
Title: The Drosophila LC8 homolog cut up specifies the axonal transport of proteasomes.
Data suggest that Ctp may interact with a Hippo pathway protein(s) to exert inverse transcriptional effects on Yorkie-target genes.
Title: Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp.
Size exclusion chromatography coupled with multiangle static light scattering demonstrates that LC8 dimers bind Ana2M sites and induce Ana2 tetramerization, yielding an Ana2M4-LC88 complex.
Title: The mechanism of dynein light chain LC8-mediated oligomerization of the Ana2 centriole duplication factor.
Dynein light chain 1 functions in somatic cyst cells to regulate spermatogonial divisions in Drosophila
Title: Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
these findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during neuroblasts asymmetric division.
Title: An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts.
LC8 binding promotes IC self-association of helix 1 from each of two IC chains, whereas LC7 binding reverses self-association by incorporating the same residues into two symmetrical, but distant, helices of the LC7-IC complex
Title: Light chain-dependent self-association of dynein intermediate chain.
Data propose bicoid mRNA localization was done by Swallow indirectly organizing the cytoskeleton, whereas Staufen plays a direct role in dynein-dependent bicoid mRNA transport.
Title: Distinguishing direct from indirect roles for bicoid mRNA localization factors.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 4688368-4688628 mobile_element_type = transposon:HMS-Beagle{}2418

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables dynein light intermediate chain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring at centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid nucleus elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by piRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of dynein complex	IDA Inferred from Direct Assay more info	PubMed
part_of dynein complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cut up

Names: 8kd dynein light chain; CG6998-PA; CG6998-PB; CG6998-PC; CG6998-PE; CG6998-PF; Cut up; ctp-PA; ctp-PB; ctp-PC; ctp-PE; ctp-PF; cytoplasmic dynein; cytoplasmic dynein 8kD light chain; cytoplasmic dynein light chain 1; dynein; dynein light chain; dynein light chain 1; dynein light chain 8; dynein light chain LC8; dynein light-chain; dynein light-chain 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

4687800..4702034

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167014.3 → NP_726942.1 cut up, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726942.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3Y5, Q24117, Q9V3Y6

UniProtKB/TrEMBL

M9NDP1

Related

FBpp0070672

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
NM_167015.3 → NP_726943.1 cut up, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726943.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3Y5, Q24117, Q9V3Y6

UniProtKB/TrEMBL

M9NDP1

Related

FBpp0070675

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
NM_001258601.3 → NP_001245530.1 cut up, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245530.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3Y5, Q24117, Q9V3Y6

UniProtKB/TrEMBL

M9NDP1

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
NM_001370042.1 → NP_001356933.1 cut up, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K1L3

Conserved Domains (1) summary

PTZ00059
Location:1 → 89

PTZ00059; dynein light chain; Provisional
NM_080336.5 → NP_525075.1 cut up, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525075.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3Y5, Q24117, Q9V3Y6

UniProtKB/TrEMBL

M9NDP1

Related

FBpp0070674

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family