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    CG14562 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14562provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037142
    Locus tag
    Dmel_CG14562
    See related
    AllianceGenome:FB:FBgn0037142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.241; Dmel\CG14562; HPS3; NP_649372
    Summary
    Predicted to be part of BLOC-2 complex. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome and Hermansky-Pudlak syndrome 3. Orthologous to human HPS3 (HPS3 biogenesis of lysosomal organelles complex 2 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14562 in Genome Data Viewer
    Location:
    79A4-79A4; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21942221..21949866)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21935321..21942966)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mushroom-body expressed Neighboring gene long non-coding RNA:CR45959 Neighboring gene SLC22A family member Neighboring gene long non-coding RNA:CR45803 Neighboring gene DNA polymerase eta Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Early origin of genes encoding subunits of biogenesis of lysosome-related organelles complex-1, -2 and -3. Cheli VT, et al. Traffic, 2010 May. PMID 20102546
    2. Peroxisomal ERK mediates Akh/glucagon action and glycemic control. Li J, et al. Cell Rep, 2023 Oct 31. PMID 37796662
    3. The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5). Falcón-Pérez JM, et al. Traffic, 2007 Feb. PMID 17156100
    4. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    5. The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster. Jehrke L, et al. Sci Rep, 2018 Apr 18. PMID 29670218, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21946256-21946377 mobile_element_type = transposon:INE-1{}2150

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in organelle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14562-PA
    CG14562-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21942221..21949866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275270.1 → NP_001262199.1  uncharacterized protein Dmel_CG14562, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNX0
      Conserved Domains (2) summary
      pfam14761
      Location:89 → 274
      HPS3_N; Hermansky-Pudlak syndrome 3
      pfam14762
      Location:527 → 828
      HPS3_Mid; Hermansky-Pudlak syndrome 3, middle region

    2. NM_141115.2 → NP_649372.1  uncharacterized protein Dmel_CG14562, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNX0
      Related
      FBpp0078125
      Conserved Domains (2) summary
      pfam14761
      Location:89 → 274
      HPS3_N; Hermansky-Pudlak syndrome 3
      pfam14762
      Location:527 → 828
      HPS3_Mid; Hermansky-Pudlak syndrome 3, middle region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZ59 Q8MZ59
    Q9VNX0 Q9VNX0

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