Pp1-87B Protein phosphatase 1 at 87B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pp1-87Bprovided by FlyBase
Official Full Name: Protein phosphatase 1 at 87Bprovided by FlyBase
Primary source: FLYBASE:FBgn0004103
Locus tag: Dmel_CG5650
See related: AllianceGenome:FB:FBgn0004103
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 87B; CG5650; ck19; Dmel\CG5650; DmPp1-87B; dPP1beta; l(3)87Bg; l(3)ck19; l(3)j6E7; Pp-1alpha; PP-1alpha; Pp1; PP1; PP1 87B; PP1 beta87b; pp1-87; pp1-87B; PP1-87B; Pp1-87Bb; Pp1.87B; pp187B; PP187B; PP1a; PP1A87B; Pp1alpha-87B; PP1alpha-87B; PP1alpha87B; PP1alpha[[2]]; PP1B; PP1c; PP1c 87B; PPI 87B; Ppl-87B; Su(var)(3)6; Su(var)3-6; Su(Var)3-6; su-var(3)6; Su-var(3)6; Suvar(3)6
Summary: Enables myosin phosphatase activity. Involved in several processes, including associative learning; chromosome organization; and positive regulation of signal transduction. Located in polytene chromosome. Part of protein phosphatase type 1 complex. Is expressed in adult head; embryonic/larval salivary gland; and spermatozoon. Used to study type 2 diabetes mellitus. Orthologous to several human genes including PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87B9-87B10; 3-52 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12423621..12425917, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8249343..8251639, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein phosphatase 1 regulates core PCP signaling.
Title: Protein phosphatase 1 regulates core PCP signaling.
Depletion of SUR-8 decreased the interaction of PER and PP1-87B, which supports the role of SUR-8 as a scaffold protein. Interestingly, the interaction between SUR-8 and PER is temporally regulated: SUR-8 has more binding to PER at night than morning. Thus, our results indicate that SUR-8 interacts with PP1-87B to control PER stability to regulate circadian rhythms.
Title: SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila.
Two mechanisms have been proposed to maintain co-orientation in Drosophila oocytes: one involves SPC105R to protect cohesins at sister centromeres, and another involves PP1-87B to regulate spindle forces at end-on attachments.
Title: Sister centromere fusion during meiosis I depends on maintaining cohesins and destabilizing microtubule attachments.
Here the authors show in vitro and in Drosophila that Protein Phosphatase 1 (PP1) inactivates Mps1 by dephosphorylating its T-loop. PP1-mediated dephosphorylation of Mps1 occurs at kinetochores and in the cytosol, and inactivation of both pools of Mps1 during metaphase is essential to ensure prompt and efficient Spindle Assembly Checkpoint silencing.
Title: Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.
Ectopic expression of dRif1 causes enlarged larval imaginal discs and early pupal lethality which is completely reversed by co-expression of PP1 87B, the major protein phosphatase in Drosophila, indicating genetic and functional interaction
Title: Drosophila Rif1 is an essential gene and controls late developmental events by direct interaction with PP1-87B.
these findings shed light on the in vivo role of the PNUTS-PP1 holoenzyme and its contribution to the control of gene expression during early Drosophila development.
Title: PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth.
PP1-87B has a role in coupling moesin-dependent cell shape changes to mitotic exit.
Title: PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit.
PP1 is not a major regulator of the Rbf1/E2F1 pathway in Drosophila
Title: Normal regulation of Rbf1/E2f1 target genes in Drosophila type 1 protein phosphatase mutants.
Bif regulates PP1 activity, and both proteins influence cytoskeleton dynamics in the growth cone of R cells to allow proper axon targeting.
Title: Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila.
PP1c not only binds TRX, but is a physiologically relevant regulator of TRX function in vivo.
Title: Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	NAS Non-traceable Author Statement more info	PubMed
involved_in locomotion	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycogen catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 1 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1 at 87B

Names: CG5650-PA; Pp1-87B-PA; protein phosphatase 1; suppressor of variegation

NP_524937.1

EC 3.-.-.-

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

12423621..12425917 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080198.3 → NP_524937.1 protein phosphatase 1 at 87B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524937.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P12982, Q4PIY5, Q9VG75

UniProtKB/TrEMBL

C0MKX3

Related

FBpp0082067

Conserved Domains (1) summary

cd07414
Location:6 → 296

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain