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    Cyp9h1 Cytochrome P450 9h1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp9h1provided by FlyBase
    Official Full Name
    Cytochrome P450 9h1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033775
    Locus tag
    Dmel_CG17577
    See related
    AllianceGenome:FB:FBgn0033775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9h1; CG17577; CYP9H1; Dmel\CG17577
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp9h1 in Genome Data Viewer
    Location:
    49D4-49D4; 2-67 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12840813..12842558, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8728318..8730063, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44453 Neighboring gene Odorant receptor 49b Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA interference validation of detoxification genes involved in ivermectin tolerance in Drosophila melanogaster. Kim JH, et al. Insect Mol Biol, 2018 Oct. PMID 29888824
    2. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Brandt A, et al. Insect Mol Biol, 2002 Aug. PMID 12144699
    3. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755
    4. Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. Shieh SY, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933837, Free PMC Article
    5. The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. King-Jones K, et al. Cell Metab, 2006 Jul. PMID 16814731

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 9h1
    Names
    CG17577-PA
    Cyp9h1-PA
    cytochrome P450
    NP_610820.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12840813..12842558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136976.2 → NP_610820.1  cytochrome P450 9h1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V6H1
      UniProtKB/TrEMBL
      F3YDG1
      Related
      FBpp0086933
      Conserved Domains (1) summary
      pfam00067
      Location:38 → 512
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V6H1.1 Q9V6H1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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