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    CG31643 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31643provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051643
    Locus tag
    Dmel_CG31643
    See related
    AllianceGenome:FB:FBgn0051643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD32258; CG31643PA; Dmel\CG31643
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; and trunk mesoderm. Orthologous to human FASTKD1 (FAST kinase domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31643 in Genome Data Viewer
    Location:
    26B3-26B3; 2-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6038117..6041283)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6038117..6041283)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene myotubularin Neighboring gene uncharacterized protein Neighboring gene Phosphoribosylformylglycinamidine synthase Neighboring gene mir-966 stem loop Neighboring gene uncharacterized protein Neighboring gene slowmo Neighboring gene Inositol phosphatase interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAP--a putative RNA-binding domain. Lee I, et al. Trends Biochem Sci, 2004 Nov. PMID 15501674
    2. Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. Velichkova M, et al. J Cell Biol, 2010 Aug 9. PMID 20696708, Free PMC Article
    3. Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein. Ashraf NS, et al. Neurobiol Dis, 2020 Apr. PMID 31783119, Free PMC Article
    4. ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Park J, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34551427, Free PMC Article
    5. A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. Port F, et al. Elife, 2020 Feb 13. PMID 32053108, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31643-PA
    CG31643-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6038117..6041283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164674.2 → NP_723145.1  uncharacterized protein Dmel_CG31643, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960W0
      Related
      FBpp0078813
      Conserved Domains (3) summary
      smart00952
      Location:834 → 894
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:647 → 713
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:736 → 816
      FAST_2; FAST kinase-like protein, subdomain 2

    2. NM_001298723.1 → NP_001285652.1  uncharacterized protein Dmel_CG31643, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960W0
      Conserved Domains (3) summary
      smart00952
      Location:834 → 894
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:647 → 713
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:736 → 816
      FAST_2; FAST kinase-like protein, subdomain 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960W0 Q960W0

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