alpha-Spec alpha Spectrin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alpha-Specprovided by FlyBase
Official Full Name: alpha Spectrinprovided by FlyBase
Primary source: FLYBASE:FBgn0250789
Locus tag: Dmel_CG1977
See related: AllianceGenome:FB:FBgn0250789
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3A9; alfa-Spec; alpha; alpha pectrin; alpha spectrin; alpha-Sp; alpha-Spc; alpha-Spe; alpha-spec; alpha-SPEC; alpha-Spect; alpha-spectrin; alpha-Spectrin; alphaSp; alphaSpec; AlphaSpec; alphaSpectrin; anon-EST:fe2E2; CG1977; Dmel\CG1977; dre3; FBtr0072789; FCP-B; klo; l(3)04276; l(3)62Bd; l(3)alpha-Spec; l(3)dre3; Sp; Spec; spectrin; Spectrin; SPTCA
Summary: Enables actin binding activity and microtubule binding activity. Involved in several processes, including long-term strengthening of neuromuscular junction; nervous system development; and oogenesis. Located in several cellular components, including basolateral plasma membrane; fusome; and lateral plasma membrane. Is expressed in several structures, including Bolwig organ; epithelial cell; fusome; ganglia; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 11; developmental and epileptic encephalopathy 5; hereditary spherocytosis; and hereditary spherocytosis type 3. Orthologous to several human genes including SPTAN1 (spectrin alpha, non-erythrocytic 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62B4-62B4; 3-1.0 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1778485..1795328, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1778485..1795328, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
Title: Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
Results define a conserved role of spectrin-based mechanical support for cilium biogenesis.
Title: Spectrin-based membrane skeleton supports ciliogenesis.
a functional spectrin-integrin complex is important for regulation of the actomyosin cytoskeleton and tissue architecture
Title: α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium.
Alpha-pectrin regulates Hippo signaling by modulating cytoskeletal actomyosin activity.
Title: Spectrin regulates Hippo signaling by modulating cortical actomyosin activity.
Our data provide the first rigorous test for the general requirement for tetramer-based non-erythroid spectrin networks throughout an organism and find that they have very limited roles, in direct contrast to the current paradigm
Title: Spectrin tetramer formation is not required for viable development in Drosophila.
Model in which alphabeta-spectrin directly couples lipid uptake at the plasma membrane to lipid droplet growth in the cytoplasm. In contrast, strong overexpression of beta-spectrin caused fat body atrophy and larval lethality.
Title: Genetic studies of spectrin in the larval fat body of Drosophila melanogaster: evidence for a novel lipid uptake apparatus.
The well-characterized interaction between AE1 and the spectrin cytoskeleton in erythrocytes is not conserved in Drosophila.
Title: The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton.
Molecular mechanisms that enhance synaptic stability despite persistent disruption of the spectrin/Ank/microtubule cytoskeleton are reported.
Title: Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton.
Specific regions of the spectrin molecule were tested for a role in polarized assembly and function.
Title: Unexpected complexity in the mechanisms that target assembly of the spectrin cytoskeleton.
At the Drosophila neuromuscular junction postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged.
Title: A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon midline choice point recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusome organization	TAS Traceable Author Statement more info	PubMed
involved_in germarium-derived female germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term strengthening of neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of presynaptic active zone structure	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte construction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian fusome organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in plasma membrane organization	TAS Traceable Author Statement more info	PubMed
acts_upstream_of positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in spectrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha spectrin

Names: CG1977-PA; CG1977-PB; CG1977-PC; CG1977-PD; aSpc 3A9; alpha-SPECTRIN; alpha-Spec-PA; alpha-Spec-PB; alpha-Spec-PC; alpha-Spec-PD; alpha-spectrin II; alphaSpectrin; anon-fast-evolving-2E2; klotzchen; spectrin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1778485..1795328 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057391.4 → NP_476739.1 alpha spectrin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476739.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13395, Q26340, Q3KN50, Q8SZW7, Q9W085

Related

FBpp0072672

Conserved Domains (5) summary

cd11808
Location:974 → 1026

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2269 → 2337

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:1614 → 1818

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:893 → 961

Spectrin; Spectrin repeat

pfam08726
Location:2344 → 2414

EFhand_Ca_insen; Ca2+ insensitive EF hand
NM_001274359.1 → NP_001261288.1 alpha spectrin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261288.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDQ0

Conserved Domains (5) summary

cd11808
Location:974 → 1026

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2279 → 2347

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:1614 → 1818

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:893 → 961

Spectrin; Spectrin repeat

pfam08726
Location:2354 → 2424

EFhand_Ca_insen; Ca2+ insensitive EF hand
NM_001274358.1 → NP_001261287.1 alpha spectrin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261287.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBI5

Conserved Domains (5) summary

cd11808
Location:974 → 1026

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2301 → 2369

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:1646 → 1850

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:893 → 961

Spectrin; Spectrin repeat

pfam08726
Location:2376 → 2446

EFhand_Ca_insen; Ca2+ insensitive EF hand
NM_001274357.1 → NP_001261286.1 alpha spectrin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261286.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGV6

Conserved Domains (5) summary

cd11808
Location:974 → 1026

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2311 → 2379

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:1646 → 1850

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:893 → 961

Spectrin; Spectrin repeat

pfam08726
Location:2386 → 2456

EFhand_Ca_insen; Ca2+ insensitive EF hand