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    Prosalpha4T1 Proteasome alpha4 subunit, Testis-specific 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosalpha4T1provided by FlyBase
    Official Full Name
    Proteasome alpha4 subunit, Testis-specific 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0265606
    Locus tag
    Dmel_CG17268
    See related
    AllianceGenome:FB:FBgn0265606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    a4-t1; alpha4t1; alpha4T1; alpha4t1_dm; CG17268; dalpha7; Dmel\CG17268; pros28.1A; Pros28.1A; Pros28.2
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in nucleus. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7) and PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosalpha4T1 in Genome Data Viewer
    Location:
    92F11-92F12; 3-69 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20748184..20749074, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16573906..16574796, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Syncrip Neighboring gene Tak1-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Turnover and lineage-specific broadening of the transcription start site in a testis-specific retrogene. Sorourian M, et al. Fly (Austin), 2010 Jan-Mar. PMID 20160503, Free PMC Article
    2. Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. Klein U, et al. J Cell Biol, 1990 Dec. PMID 2126012, Free PMC Article
    3. Duplicated proteasome subunit genes in Drosophila melanogaster encoding testes-specific isoforms. Yuan X, et al. Genetics, 1996 Sep. PMID 8878681, Free PMC Article
    4. Evolutionary conservation of a testes-specific proteasome subunit gene in Drosophila. Belote JM, et al. Gene, 1998 Jul 17. PMID 9666090
    5. Relocation facilitates the acquisition of short cis-regulatory regions that drive the expression of retrogenes during spermatogenesis in Drosophila. Sorourian M, et al. Mol Biol Evol, 2014 Aug. PMID 24855141, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha4 subunit, Testis-specific 1
    Names
    20s proteasome
    CG17268-PA
    Pros28.1A
    Prosalpha4T1-PA
    proteasome 28kD subunit 1A
    proteasome 28kD subunit 2
    testes-specific proteasome subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20748184..20749074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142653.3 → NP_650910.1  proteasome alpha4 subunit, Testis-specific 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650910.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24178, Q6QH19, Q8T8U0, Q9VDJ1
      UniProtKB/TrEMBL
      S5ML38
      Related
      FBpp0083336
      Conserved Domains (2) summary
      PRK03996
      Location:5 → 239
      PRK03996; proteasome subunit alpha; Provisional
      cd03755
      Location:5 → 213
      proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24178.2 Q24178

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