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    mTTF mitochondrial transcription termination factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mTTFprovided by FlyBase
    Official Full Name
    mitochondrial transcription termination factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028530
    Locus tag
    Dmel_CG18124
    See related
    AllianceGenome:FB:FBgn0028530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS01068.4; CG18124; Dmel\CG18124; DmTTF; DS01068.4; TTF
    Summary
    Enables DNA binding activity. Involved in termination of mitochondrial transcription. Located in mitochondrion. Is expressed in adult head and spermatozoon. Orthologous to human MTERF1 (mitochondrial transcription termination factor 1) and MTERF2 (mitochondrial transcription termination factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mTTF in Genome Data Viewer
    Location:
    35A4-35A4; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14347239..14348790, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14347239..14348790, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spermathecal endopeptidase 2 Neighboring gene antisense RNA:CR44850 Neighboring gene lethal (2) 34Fc Neighboring gene uncharacterized protein Neighboring gene lethal (2) 34Fd

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro transcription termination activity of the Drosophila mitochondrial DNA-binding protein DmTTF. Roberti M, et al. Biochem Biophys Res Commun, 2005 May 27. PMID 15845400
    2. The Drosophila termination factor DmTTF regulates in vivo mitochondrial transcription. Roberti M, et al. Nucleic Acids Res, 2006. PMID 16648357, Free PMC Article
    3. The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial transcription termination factor DmTTF. Fernández-Moreno MA, et al. Biochem J, 2009 Mar 1. PMID 19032147
    4. Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. Jõers P, et al. PLoS Genet, 2013. PMID 24068965, Free PMC Article
    5. DmTTF, a novel mitochondrial transcription termination factor that recognises two sequences of Drosophila melanogaster mitochondrial DNA. Roberti M, et al. Nucleic Acids Res, 2003 Mar 15. PMID 12626700, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mTerf5 knockdown led to enhanced replication pausing at mTTF binding sites, a decrease in fragile replication intermediates containing single-stranded segments, and the disappearance of species containing segments of RNA/DNA hybrid
      Title: Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis.
    2. DmTTF might play multiple roles in the mtDNA transcription process, for which different levels of the protein with respect to mtRNApol are required.
      Title: The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial transcription termination factor DmTTF.
    3. The first ever-obtained evidence for an in vivo role of an animal mitochondrial transcription termination factor.
      Title: The Drosophila termination factor DmTTF regulates in vivo mitochondrial transcription.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in termination of mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of mitochondrial transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial transcription termination factor
    Names
    CG18124-PA
    mTTF-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14347239..14348790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135865.4 → NP_609709.1  mitochondrial transcription termination factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609709.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86LS0, Q9V3F3
      Related
      FBpp0080213
      Conserved Domains (1) summary
      cl19765
      Location:284 → 378
      mTERF; mTERF
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3F3.1 Q9V3F3

    Gene LinkOut

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